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Chromosomal changes associated with clinical outcome in lymph node-negative breast cancer
Department of Oncology, Institute of Clinical Sciences, Göteborg University, Blå stråket 2, SE-413 45 Göteborg, Sweden.
Department of Oncology, Institute of Clinical Sciences, Göteborg University, Blå stråket 2, SE-413 45 Göteborg, Sweden.
Department of Oncology, Institute of Clinical Sciences, Göteborg University, Blå stråket 2, SE-413 45 Göteborg, Sweden.
University of Skövde, School of Humanities and Informatics.
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2007 (English)In: Cancer Genetics and Cytogenetics, ISSN 0165-4608, E-ISSN 1873-4456, Vol. 172, no 2, 139-146 p.Article in journal (Refereed) Published
Abstract [en]

Breast cancer is the most common malignancy among women and accounts for over one million new cases worldwide per year. Lymph node-negative breast cancer patients are reputed as having a better prognosis than lymph node-positive ones. Around 20% of the lymph node-negative patients die within 10 years after diagnosis. To improve the prognostics of node-negative breast cancer, it is important to understand the underlying biologic mechanisms promoting survival, such as specific genetic changes in the tumor genome. In this study, CGH was applied to analyze 64 tumors from node-negative breast cancer patients to identify DNA copy number changes in chromosomes and chromosome regions that may be correlated to survival. The main findings show gains at 4q, 5q31not, vert, similarqter, 6q12not, vert, similarq16, and 12q14not, vert, similarq22, as well as losses of 17p, 18p, and Xq, which were significantly more recurrent in tumors from deceased patients than in tumors from survivors. The average number of chromosomal changes was higher in the tumors from deceased compared to the survivor tumors. Our findings suggest that tumors with specific chromosomal aberrations at 4q, 5q31not, vert, similarqter, 6q12not, vert, similarq16, 12q14not, vert, similarq22, 17p, 18p, and Xq result in an aggressive form of breast cancer and that these patients are predisposed to succumb to breast cancer.

Place, publisher, year, edition, pages
Elsevier, 2007. Vol. 172, no 2, 139-146 p.
Identifiers
URN: urn:nbn:se:his:diva-1997DOI: 10.1016/j.cancergencyto.2006.09.019ISI: 000243672300006PubMedID: 17213022Scopus ID: 2-s2.0-33846010199OAI: oai:DiVA.org:his-1997DiVA: diva2:32273
Available from: 2008-04-21 Created: 2008-04-21 Last updated: 2013-04-11Bibliographically approved

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