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Allelic imbalance on chromosome 10 in rat endometrial adenocarcinomas
Lundberg Laboratory, CMB-Genetics, Göteborg Univ., Box 462, SE-40530 G., Sweden / Department of Pathology, Lundberg Lab. for Cancer Research, Göteborg, Sweden, Sweden.
Department of Pathology, Lundberg Lab. for Cancer Research, Göteborg, Sweden.
Lundberg Laboratory, CMB-Genetics, Göteborg Univ., Box 462, SE-40530 G., Sweden.
University of Skövde, School of Life Sciences.
2005 (English)In: Cancer Genetics and Cytogenetics, ISSN 0165-4608, E-ISSN 1873-4456, Vol. 156, no 2, 158-166 p.Article in journal (Refereed) Published
Abstract [en]

Earlier work using comparative genome hybridization (CGH) has shown that rat chromosome 10 (RNO10) is frequently involved in cytogenetic aberrations in BDII rat endometrial adenocarcinomas (EAC). Relative reduction in copy number (chromosomal deletions) was seen in the proximal to middle part of the chromosome, whereas there were increases in copy number in the distal part. The occurrence of RNO10 aberrations was further analyzed in DNA from primary tumor material from 42 EACs and 3 benign endometrial tumors using allelotyping of microsatellite markers. We found frequently that there were 4 quite distinct RNO10 regions that exhibited allelic imbalance. Based on these findings we believe that genes with relevance to EAC tumor development are situated in each of these chromosome regions. Extrapolation of our microsatellite marker data to the rat draft DNA sequence will facilitate the definition of the regions at the level of the DNA and to select and characterize candidate genes within each of the affected chromosome regions.

Place, publisher, year, edition, pages
Elsevier, 2005. Vol. 156, no 2, 158-166 p.
National Category
Medical and Health Sciences
Research subject
Medical sciences
Identifiers
URN: urn:nbn:se:his:diva-1577DOI: 10.1016/j.cancergencyto.2004.05.001ISI: 000226686000010PubMedID: 15642397Scopus ID: 2-s2.0-11844269305OAI: oai:DiVA.org:his-1577DiVA: diva2:31853
Available from: 2007-07-23 Created: 2007-07-23 Last updated: 2013-01-21Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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