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Deriving Protein Networks by Combining Gene Expression and Protein Chip Analysis
University of Skövde, Department of Computer Science.
2002 (English)Independent thesis Advanced level (degree of Master (One Year))Student thesis
Abstract [en]

In order to derive reliable protein networks it has recently been suggested that the combination of information from both gene and protein level is required. In this thesis a combination of gene expression and protein chip analysis was performed when constructing protein networks. Proteins with high affinity to the same substrates and encoded by genes with high correlation is here thought to constitute reliable protein networks. The protein networks derived are unfortunately not as reliable as were hoped for. According to the tests performed, the method derived in this thesis does not perform more than slightly better than chance. However, the poor results can depend on the data used, since mismatching and shortage of data has been evident.

Place, publisher, year, edition, pages
Skövde: Institutionen för datavetenskap , 2002. , 77 p.
Keyword [en]
Protein networks, protein chips, gene expression analysis
National Category
Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:his:diva-706OAI: oai:DiVA.org:his-706DiVA: diva2:3106
Presentation
(English)
Uppsok
Physics, Chemistry, Mathematics
Supervisors
Available from: 2008-02-04 Created: 2008-02-04 Last updated: 2010-02-05

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf