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Developing Semantic Pathway Comparison Methods for Systems Biology
University of Skövde, School of Humanities and Informatics. University of Skövde, The Systems Biology Research Centre.
2009 (English)Doctoral thesis, monograph (Other academic)
Abstract [en]

Systems biology is an emerging multi-disciplinary field in which the behaviour of complex biological systems is studied by considering the interaction of many cellular and molecular constituents rather than using a “traditional” reductionist approach where constituents are studied individually. Systems are often studied over time with the ultimate goal of developing models which can be used to understand and predict complex biological processes, such as human diseases. To support systems biology, a large number of biological pathways are being derived for many different organisms, and these are stored in various databases. This pathway collection presents an opportunity to compare and contrast pathways, and to utilise the knowledge they represent. This thesis presents some of the first algorithms that are designed to explore this opportunity. It is argued that the methods will be useful to biologists in order to assess the biological plausibility of derived pathways, compare different biological pathways for semantic similarities, and to derive putative pathways that are semantically similar to documented biological pathways. The methods will therefore extend the systems biology toolbox that biologists can use to make new biological discoveries.

Place, publisher, year, edition, pages
Edinburgh, UK: Heriot-Watt University , 2009. , 175 p.
National Category
Engineering and Technology
Research subject
Technology
Identifiers
URN: urn:nbn:se:his:diva-3532OAI: oai:DiVA.org:his-3532DiVA: diva2:284146
Public defence
(English)
Available from: 2010-01-19 Created: 2010-01-04 Last updated: 2013-04-16Bibliographically approved

Open Access in DiVA

No full text

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http://www.hwurpa.hw.ac.uk/handle/10399/2294

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  • apa
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