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Regulation of 'stemness' and stem cell differentiation by microRNAs
Cellartis AB, Arvid Wallgrens Backe 20, SE-413 46 Göteborg, Sweden.
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
Cellartis AB, Arvid Wallgrens Backe 20, SE-413 46 Göteborg, Sweden.
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
2009 (English)In: IDrugs. The Investigational Drugs Journal, ISSN 1369-7056, Vol. 12, no 8, 492-496 p.Article, review/survey (Refereed) Published
Abstract [en]

Pluripotency and cellular differentiation are intricate biological processes that are coordinately regulated by a complex set of factors and epigenetic regulators. Human pluripotent stem cell lines can be generated from surplus fertilized eggs or, as demonstrated more recently, from the reprogramming of somatic cells. Standardized culture conditions for the long-term maintenance and propagation of undifferentiated human pluripotent stem cells have also been developed. An objective of current research is to increase the understanding of the molecular mechanisms that regulate stem cell differentiation. The differentiation of human pluripotent stem cells may enable the generation of large quantities of specialized cells that can be used as in vitro tools for drug development, as well as for future applications in regenerative medicine. However, most of the currently used differentiation protocols yield inefficient stem cell quantities and low purity of the final cell preparations. The discovery of microRNAs (miRNAs) and their role as important transcriptional regulators may provide a new means of manipulating stem cell fate. This article provides an overview of some recent advancements made in the fields of both stem cell biology and miRNA.

Place, publisher, year, edition, pages
BioMed Central, 2009. Vol. 12, no 8, 492-496 p.
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-3513ISI: 000268223700010PubMedID: 19629883Scopus ID: 2-s2.0-68549118772OAI: oai:DiVA.org:his-3513DiVA: diva2:279023
Available from: 2009-12-01 Created: 2009-12-01 Last updated: 2013-09-11Bibliographically approved

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PubMedScopushttp://www.biomedcentral.com/render/render.asp?arx_id=cd-1027451&type=pdf&access=denied

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CiteExportLink to record
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