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A Kinetic Overview of the Receptors Involved in 1,25-Dihydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 Signaling: A Systems Biology Approach
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
2009 (English)In: Critical Reviews in Eukaryotic Gene Expression, ISSN 1045-4403, Vol. 19, no 3, 181-196 p.Article, review/survey (Refereed) Published
Abstract [en]

The vitamin D endocrine system modulates an arsenal of important biological functions in more than 30 different tissues in short- and long-term perspectives. Two membrane receptors and one nuclear receptor are suggested to be involved in the vitamin D signaling system, but the function and physiological relevance of the receptors are debated. The complexity of the vitamin D endocrine system makes it necessary to combine experimental data with in silico simulations to get a holistic view of vitamin D-dependent regulation of tissue and cell physiology. This review focus on binding characteristics for the three putative vitamin D receptors and proposes a future systems biology approach including mathematical modeling that will be helpful together with experimental methods in depicting antitumoral and other biological effects promoted by the vitamin D endocrine system.

Place, publisher, year, edition, pages
Begell House, 2009. Vol. 19, no 3, 181-196 p.
Keyword [en]
vitamin D, mathematical modeling, nVDR, PDIA3, catalase, receptor kinetics
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-3510DOI: 10.1615/CritRevEukarGeneExpr.v19.i3.20ISI: 000270313600003PubMedID: 19883364Scopus ID: 2-s2.0-67650314922OAI: oai:DiVA.org:his-3510DiVA: diva2:278993
Available from: 2009-12-01 Created: 2009-12-01 Last updated: 2013-09-10Bibliographically approved

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Holmén, JonathanJansson, AndreasLarsson, Dennis
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CiteExportLink to record
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Citation style
  • apa
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More styles
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