his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Differential effects of repeated long and brief maternal separation on behaviour and neuroendocrine parameters in Wistar dams
Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
Department of Animal Environment and Health, Swedish University of Agriculture, P.O. Box 234, SE-532 23 Skara, Sweden.
Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
2009 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 203, no 1, 69-75 p.Article in journal (Refereed) Published
Abstract [en]

Repeated, prolonged maternal separation has been suggested to model the development of a depression-like syndrome in rats. The long separations from the pups have been proposed to be stressful for the dams, which in turn could mediate the changes seen in adult offspring. In the present study we investigated whether prolonged maternal separation really is stressful for rat dams by studying parameters known to be affected by long-term stress such as spontaneous motor activity, anxiety-like behaviour, adrenal gland weight and plasma corticosterone levels. Dams were separated from their litter for either 4 h (MS240) or 15 min (MS15) on eight random days during postnatal day 1–14, or left undisturbed (animal facility reared, AFR). After weaning MS240 dams showed decreased peripheral activity and habituated slower in horizontal activity. On the contrary, MS15 dams showed more peripheral activity and less rearing activity compared to both AFR and MS240 dams when habituated to the testing apparatus, suggesting that MS15 dams are more anxious. The adrenal glands from MS15 dams weighed significantly less and plasma corticosterone levels were significantly higher compared to AFR and MS240 dams. These results suggest that repeated brief maternal separations from pups could be stressful for rat mothers, whereas prolonged separations are not. Since these results are in contrast to the current notion that the short separation procedure may be considered as a safe milieu, whereas the prolonged separations have been suggested to be stressful for both dams and pups, further studies in this field are warranted.

Place, publisher, year, edition, pages
Elsevier, 2009. Vol. 203, no 1, 69-75 p.
Keyword [en]
Early environment; Anxiety-like behaviour; Spontaneous motor activity; Hypothalamic–pituitary–adrenal axis; Corticosterone; Stress
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-3294DOI: 10.1016/j.bbr.2009.04.017ISI: 000267961400010PubMedID: 19394366Scopus ID: 2-s2.0-67349153383OAI: oai:DiVA.org:his-3294DiVA: diva2:227142
Available from: 2009-07-09 Created: 2009-07-09 Last updated: 2013-03-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Johansson, Linda
By organisation
The Systems Biology Research CentreSchool of Life Sciences
In the same journal
Behavioural Brain Research
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 697 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf