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Effects of Intrapartum Oxytocin Administration and Epidural Analgesia on the Concentration of Plasma Oxytocin and Prolactin, in Response to Suckling During the Second Day Postpartum
Division of Reproductive and Perinatal Heath Care, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden.
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences. Department of Animal Environment and Health, Swedish University of Agriculture, Skara, Sweden.ORCID iD: 0000-0003-0987-8357
University of Skövde, School of Life Sciences. Division of Reproductive and Perinatal Heath Care, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-0092-0822
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.ORCID iD: 0000-0002-3053-4543
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2009 (English)In: Breastfeeding Medicine, ISSN 1556-8253, E-ISSN 1556-8342, Vol. 4, no 2, p. 71-82Article in journal (Refereed) Published
Abstract [en]

Background: Oxytocin and prolactin stimulate milk ejection and milk production during breastfeeding. The aim of the present study was to make a detailed analysis of maternal release of oxytocin and prolactin in response to breastfeeding during the second day postpartum in mothers who had received oxytocin either intravenously for stimulation of labor or intramuscularly for prevention of postpartum hemorrhage and/or epidural analgesia or those who had received no such treatment in connection with birth.

Methods: In a descriptive comparative study plasma oxytocin and prolactin concentrations were measured in response to suckling during the second day postpartum in women who had received intravenous intrapartum oxytocin (n = 8), intramuscular postpartum oxytocin (n = 13), or epidural analgesia, either with (n = 14) or without (n = 6) intrapartum oxytocin infusion, and women who received none of these interventions (n = 20). Hormone levels were analyzed by enzyme immunoassay.

Results: All mothers showed a pulsatile oxytocin pattern during the first 10 minutes of breastfeeding. Women who had received epidural analgesia with oxytocin infusion had the lowest endogenous median oxytocin levels. The more oxytocin infusion the mothers had received during labor, the lower their endogenous oxytocin levels were during a breastfeeding during the second day postpartum. A significant rise of prolactin was observed after 20 minutes in all women, but after 10 minutes in mothers having received oxytocin infusion during labor. In all women, oxytocin variability and the rise of prolactin levels between 0 and 20 minutes correlated significantly with median oxytocin and prolactin levels.

Conclusion: Oxytocin, released in a pulsatile way, and prolactin were released by breastfeeding during the second day postpartum. Oxytocin infusion decreased endogenous oxytocin levels dose-dependently. Furthermore, oxytocin infusion facilitated the release of prolactin. Epidural analgesia in combination with oxytocin infusion influenced endogenous oxytocin levels negatively.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2009. Vol. 4, no 2, p. 71-82
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-3292DOI: 10.1089/bfm.2008.0002ISI: 000276674000004PubMedID: 19210132Scopus ID: 2-s2.0-67649939196OAI: oai:DiVA.org:his-3292DiVA, id: diva2:227129
Available from: 2009-07-09 Created: 2009-07-09 Last updated: 2023-09-07Bibliographically approved
In thesis
1. Human-Human and Human-Animal Interaction: Some Common Physiological and Psychological Effects
Open this publication in new window or tab >>Human-Human and Human-Animal Interaction: Some Common Physiological and Psychological Effects
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of the present thesis was to investigate hormonal and physiological effects in mothers during a breastfeeding session and in dogs and their owners in response to short-term interaction. In study one, sixty-six mothers receiving either exogenous oxytocin infusion and/or epidural analgesia (EDA) during labor or intramuscular oxytocin injection post partum were studied. Oxytocin, prolactin, adrenocorticotrophic hormone (ACTH) and cortisol levels, as well as blood pressure were measured during a breastfeeding session two days after birth. In response to breastfeeding two days after birth, the mothers displayed a pulsatile release of oxytocin and increasing prolactin levels. In addition, the activity in the HPA-axis was reduced and maternal blood pressure decreased. The results also show that EDA administration in combination with oxytocin during labor resulted insignificantly lower oxytocin levels and higher cortisol levels, as well as higher bloodpressure in response to breastfeeding two days after birth, compared to EDA administration alone. In addition, oxytocin infusions dose-dependently lowered the mothers’ endogenous oxytocin levels two days after birth. In study two, ten female dog owners and their male Labrador dogs participated, together with ten controls. Their levels of oxytocin, cortisol and insulin, as well as their heart rate, were measured. The connection between the quality of the dogowner relationship and hormone levels was also explored. Short-term interaction between dogs and their owners resulted in oxytocin release in both species and their cortisol levels and heart rate were also affected. Oxytocin levels and positive attitudes regarding the dog-owner relationship were positively correlated. In conclusion, both human-human and human-animal interactions induce oxytocin release and promote oxytocin mediated effects, such as decreasing cortisol levels and blood pressure. In addition, social interaction and oxytocin levels arepositively related.

Place, publisher, year, edition, pages
Swedish University of Agricultural Sciences, 2010. p. 88
Series
Acta Universitatis agriculturae Sueciae, ISSN 1652-6880 ; 2010:98
Keywords
oxytocin, cortisol, prolactin, ACTH, blood pressure, medical interventions, sensory stimulation, interaction
National Category
Clinical Science Behavioral Sciences Biology Animal and Dairy Science Other Veterinary Science Obstetrics, Gynecology and Reproductive Medicine
Research subject
Natural sciences
Identifiers
urn:nbn:se:his:diva-5212 (URN)978-91-576-7543-9 (ISBN)
Public defence
2011-01-14, Hernqvistaulan, Skara, 13:00 (English)
Opponent
Supervisors
Available from: 2011-07-05 Created: 2011-07-05 Last updated: 2021-09-06Bibliographically approved

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Johansson, Linda M.Nissen, EvaEjdebäck, Mikael

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