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Neurobiological aspect of suicide; a review of low cerebrospinal 5 hydroxyindoleacetic acid concentration and prediction of suicidality
University of Skövde, School of Life Sciences.
2007 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Finding an indicator that can point to a high risk group for suicide has long been a desirable aid for the prevention of completed suicides. The studies reviewed in this essay presume that a biological aspect can point out the high risk individual. The focus of the studies lies on the serotonin 5-hydroxytryptamine (5-HT) monoamine neurotransmitter and cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) which is the principal metabolite of 5-HT in depression. The studies on 5-HT metabolites have led to the belief that these may play a key role in the neurochemistry of suicidal behaviour. It is suggested that the core behavioural effect of low CSF 5-HIAA concentration might result in an increase in impulsive and violent behaviour to self and others. The predictability is based on the fact that patients with low CSF 5-HIAA are more prone to reattempt and complete suicide by violent means. A number of well-designed studies concerning suicidal individuals and control subjects have however not shown any difference in concentration of CSF 5-HIAA in suicide attempters compared to non-suicide attempters which could be explained by methodological flaws. Low CSF 5-HIAA does seem to characterize the high risk individual, but it is not yet determined what role it plays in actual suicidality.

Place, publisher, year, edition, pages
Skövde: Institutionen för kommunikation och information , 2007. , 29 p.
Keyword [en]
CSF 5-HIAA, Suicide attempts, suicide, serotonin, 5-hydroxyindoleacetic acid, depression, neurobiology of suicide.
National Category
Human Computer Interaction
Identifiers
URN: urn:nbn:se:his:diva-102OAI: oai:DiVA.org:his-102DiVA: diva2:2132
Subject / course
Cognitive Science
Educational program
Cognitive Science - Study Programme
Presentation
(English)
Uppsok
Technology
Supervisors
Examiners
Available from: 2007-06-20 Created: 2007-06-20 Last updated: 2012-11-20

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CiteExportLink to record
Permanent link

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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
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  • Other locale
More languages
Output format
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