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The impact of DNA methylation in forensics criminal investigations: A meta-analysis
University of Skövde, School of Bioscience.
2024 (English)Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

This study examines the use of DNA methylation as an application in forensic science, namely age estimation and individual identification. DNA methylation is an epigenetic marker that assists forensic analyses by providing information about biological age and tissue types. A meta-analysis methodology that integrated data from 15 research papers was utilized to evaluate the precision and reliability of age predictions based on DNA methylation. The findings indicate that DNA methylation is a valid method for age determination, which is especially useful when traditional forensic methods are insufficient on degraded biological samples. The outcomes suggest a high overall effect, with an effect size (r) of 0.96, and a 95% confidence interval of 0.94 to 0.97. Given the variations in sample sizes and methodologies across the publications, slight differences in the MAD values were expected. Nevertheless, these values remained within a comparable range. The results imply that DNA methylation markers are highly effective for age estimate, particularly in genes KLF14 and ELOVL2 where there is a strong association between CpG sites and age. In conclusion, DNA methylation is a practical and essential technique for establishing age and identifying individuals. The study emphasizes how DNA methylation can improve forensic procedures and age estimation accuracy, potentially aiding in the resolution of criminal cases. 

Place, publisher, year, edition, pages
2024. , p. 20
Keywords [en]
Age estimation, forensic science, DNA methylation, individual identification
National Category
Medical Bioscience
Identifiers
URN: urn:nbn:se:his:diva-24278OAI: oai:DiVA.org:his-24278DiVA, id: diva2:1883074
Subject / course
Bioscience
Educational program
Bioscience - Molecular Biodesign
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Available from: 2024-07-08 Created: 2024-07-08 Last updated: 2024-07-08Bibliographically approved

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