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Cerebral blood flow & menopausal status: Characterizing the effects of menstrual phase and menopausal status on cerebral blood flow control
University of Skövde, School of Health Sciences.
2024 (English)Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Cerebrovascular risks and neurodegenerative diseases in women, especially linked to menopause, are increasingly associated with cerebral blood flow (CBF) control. With stroke risk and other cerebrovascular events being higher in women and even higher after menopause, understanding the mechanisms driving these processes is pivotal for achieving appropriate healthcare outcomes. This study aimed to characterize the impact of menstrual cycle phase and menopausal status on cerebral blood flow control. Neurovascular coupling (NVC) and cerebrovascular reactivity (CVR) were the focusof this experiment in observing blood flow control and hypercapnia responses through insonation of the middle cerebral and posterior cerebral arteries. In assessing participants across the menstrual cycle and menopause, the study aimed to observe the implications of hormonal fluctuations on NVC and CVR. Results of this experiment indicated significance in NVC between the premenopausal and postmenopausal states within the first visit corresponding to the follicular phase of the menstrual cycle. Contrary to the initial hypothesis, hypercapnia testing results did not show any significant differences in CVR. This study illustrates significant differences in NVC through CBF in the post cerebral artery between menopausal states in the first visit/follicular phase, but the same is not observed across all parameters of analysis. The conducted study has limitations including baseline corrections, hormonal measurements, and specifying parameters for the onset of menopause. Implementing these could potentially improve this study’s results in the future. Investigating these vital aspects of CBF control can provide valuable insights regarding the cerebrovascular health of women.

Place, publisher, year, edition, pages
2024. , p. 35
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:his:diva-23952OAI: oai:DiVA.org:his-23952DiVA, id: diva2:1871297
External cooperation
University College of Cork
Subject / course
Biomedicine/Medical Science
Educational program
Biomedicine - Study Programme
Supervisors
Examiners
Available from: 2024-06-17 Created: 2024-06-17 Last updated: 2024-06-17Bibliographically approved

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CiteExportLink to record
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Citation style
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