Depression has increased among adolescents and adults over the last decade. Effective treatments and techniques to improve personal well being and disorders like depression are much needed. Mindfulness is a psychological technique that involves actively paying attention to one's awareness of the present moment with nonjudgmental acceptance (Kabat-Zinn, 1990). While the effectiveness of mindfulness interventions has been widely studied, relatively little research has been done on the effects of mindfulness interventions on depression using neuroimaging techniques such as functional magnetic resonance imaging (fMRI) or electroencephalography (EEG). This systematic review includes four studies that investigates the effectiveness of mindfulness interventions on depression measured by fMRI or EEG and different rating scales measuring depression. The results from this systematic review shows that mindfulness interventions may have an effect on depression. Two of the studies (Ferri et al., (2017); Yang et al., (2016), found significant differences in the rating scales for depression. The studies also suggest that mindfulness interventions can impact the brain regions involved in negative emotional processing in individuals with depression, such as the default mode network (DMN) and the dorsal anterior cingulate cortex (dACC).