This systematic review aimed to examine if there is a reduction of stress after participating in the Mindfulness-based stress reduction eight-week program. Stress is a global health problem and statistical measures present a year-to-year increase in stress levels (Gallup, 2022; WHO, 2023). MBSR is an eight-week program with roots in Eastern culture and was developed by Jon Kabat-Zinn (2013) to reduce stress and increase well-being. The search string used for this systematic review was carried out in Web of Science and Scopus to identify original research and peer review papers. Three studies met the inclusion criteria and are included in this review. The three studies used heart rate variability (HRV) and questionnaires to measure the effect of MBSR on stress. Findings in this systematic review highlights significant results related to stress reduction from participating in the MBSR program. Conclusively, the MBSR program contributes to more possibilities to reduce stress in society. This is of great importance since stress is growing extensively on a global scale. Thus, it is of greater importance to find and develop more evidence-based methods and resources which are easily accessible to the general population with low or no cost which MBSR offer.