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Severe Infection and Risk of Cardiovascular Disease: A Multicohort Study
Department of Public Health, University of Helsinki, Finland ; Finnish Institute of Occupational Health, Helsinki, Finland.
Department of Public Health, University of Helsinki, Finland ; UCL Brain Sciences, University College London, United Kingdom.
UCL Brain Sciences, University College London, United Kingdom.
Department of Bacteriology and Immunology and Translational Immunology Research Program, University of Helsinki, Finland.
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2023 (English)In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 147, no 21, p. 1582-1593Article in journal (Refereed) Published
Abstract [en]

Background: The excess risk of cardiovascular disease associated with a wide array of infectious diseases is unknown. We quantified the short- and long-term risk of major cardiovascular events in people with severe infection and estimated the population-attributable fraction. Methods: We analyzed data from 331 683 UK Biobank participants without cardiovascular disease at baseline (2006-2010) and replicated our main findings in an independent population from 3 prospective cohort studies comprising 271 329 community-dwelling participants from Finland (baseline 1986-2005). Cardiovascular risk factors were measured at baseline. We diagnosed infectious diseases (the exposure) and incident major cardiovascular events after infections, defined as myocardial infarction, cardiac death, or fatal or nonfatal stroke (the outcome) from linkage of participants to hospital and death registers. We computed adjusted hazard ratios (HRs) and 95% CIs for infectious diseases as short- and long-term risk factors for incident major cardiovascular events. We also calculated population-attributable fractions for long-term risk. Results: In the UK Biobank (mean follow-up, 11.6 years), 54 434 participants were hospitalized for an infection, and 11 649 had an incident major cardiovascular event at follow-up. Relative to participants with no record of infectious disease, those who were hospitalized experienced increased risk of major cardiovascular events, largely irrespective of the type of infection. This association was strongest during the first month after infection (HR, 7.87 [95% CI, 6.36-9.73]), but remained elevated during the entire follow-up (HR, 1.47 [95% CI, 1.40-1.54]). The findings were similar in the replication cohort (HR, 7.64 [95% CI, 5.82-10.03] during the first month; HR, 1.41 [95% CI, 1.34-1.48] during mean follow-up of 19.2 years). After controlling for traditional cardiovascular risk factors, the population-attributable fraction for severe infections and major cardiovascular events was 4.4% in the UK Biobank and 6.1% in the replication cohort. Conclusions: Infections severe enough to require hospital treatment were associated with increased risks for major cardiovascular disease events immediately after hospitalization. A small excess risk was also observed in the long-term, but residual confounding cannot be excluded.

Place, publisher, year, edition, pages
American Heart Association , 2023. Vol. 147, no 21, p. 1582-1593
Keywords [en]
cohort studies, communicable diseases, myocardial infarction, stroke, Cardiovascular Diseases, Humans, Prospective Studies, Risk Factors, cardiovascular disease, communicable disease, complication, heart infarction, human, prospective study, risk factor
National Category
Public Health, Global Health, Social Medicine and Epidemiology Cardiac and Cardiovascular Systems
Research subject
Research on Citizen Centered Health, University of Skövde (Reacch US)
Identifiers
URN: urn:nbn:se:his:diva-22655DOI: 10.1161/CIRCULATIONAHA.122.061183ISI: 000991896400004PubMedID: 36971007Scopus ID: 2-s2.0-85160208376OAI: oai:DiVA.org:his-22655DiVA, id: diva2:1764322
Funder
NordForsk, 75021Academy of Finland, 329202, 350426, 311492, 321409, 329240Wellcome trust, 201440/Z/16/Z, 221854/Z/20/Z
Note

CC BY 4.0

Correspondence to: Pyry Sipilä, Clinicum, Department of Public Health, PO Box 20, FI-00014 University of Helsinki, Finland. Email pyry.sipila@helsinki.fi

Acknowledgments

This research was conducted using data from the UK Biobank (https://www.ukbiobank.ac.uk/) via application 60565.

Sources of Funding

This work was funded in whole, or in part, by grants from NordForsk (75021), Academy of Finland (329202 and 350426), Helsinki Institute of Life Science, Emil Aaltonen Foundation, Finnish Medical Foundation, Päivikki and Sakari Sohlberg Foundation, Finnish Foundation for Cardiovascular Research (a86898), US National Institute on Aging (R01AG056477, 1R56AG052519-01, and 1R01AG052519-01A1), UK Medical Research Council (MRC S011676/1, R024227/1, and MR/P023444/1), and Wellcome Trust (201440/Z/16/Z and 221854/Z/20/Z). The funders had no role in study design, data collection, analysis, or interpretation, or writing of the report or decision to submit it for publication.

Disclosures

Dr Sipilä reports grant support during the conduct of the study from NordForsk (75021), Academy of Finland (311492 and 329202), Helsinki Institute of Life Science, Emil Aaltonen Foundation, and Finnish Medical Foundation. Dr Lindbohm reports grant support during the conduct of the study from the Academy of Finland (339568) and Päivikki and Sakari Sohlberg Foundation. Dr Batty reports grant support from the UK Medical Research Council (MR/P023444/1) and US National Institute on Aging (1R56AG052519-01 and 1R01AG052519-01A1). Dr Vahtera reports grant support from the Academy of Finland (321409 and 329240) and NordForsk (75021). Dr Nyberg reports grant support from NordForsk (75021). Dr Warren-Gash reports support from Wellcome Fellowship (201440/Z/16/Z). Dr Kivimäki reports grant support during the conduct of the study from NordForsk (75021), UK Medical Research Council (MRC S011676/1 and R024227/1), US National Institute on Aging (R01AG056477), Academy of Finland (329202 and 350426), Finnish Foundation for Cardiovascular Research (a86898), Finnish Work Environment Fund (190424), and Wellcome Trust (221854/Z/20/Z). The other authors report no conflicts.

Available from: 2023-06-08 Created: 2023-06-08 Last updated: 2023-07-14Bibliographically approved

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