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Early Prediction of Dementia Using Feature Extraction Battery (FEB) and Optimized Support Vector Machine (SVM) for Classification
Aging Research Center, Karolinska Institutet, Stockholm, Sweden;Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0003-4190-3532
Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0002-6752-017X
Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0003-4312-2246
Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.
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2023 (English)In: Biomedicines, E-ISSN 2227-9059, Vol. 11, no 2, article id 439Article in journal (Refereed) Published
Abstract [en]

Dementia is a cognitive disorder that mainly targets older adults. At present, dementia has no cure or prevention available. Scientists found that dementia symptoms might emerge as early as ten years before the onset of real disease. As a result, machine learning (ML) scientists developed various techniques for the early prediction of dementia using dementia symptoms. However, these methods have fundamental limitations, such as low accuracy and bias in machine learning (ML) models. To resolve the issue of bias in the proposed ML model, we deployed the adaptive synthetic sampling (ADASYN) technique, and to improve accuracy, we have proposed novel feature extraction techniques, namely, feature extraction battery (FEB) and optimized support vector machine (SVM) using radical basis function (rbf) for the classification of the disease. The hyperparameters of SVM are calibrated by employing the grid search approach. It is evident from the experimental results that the newly proposed model (FEB-SVM) improves the dementia prediction accuracy of the conventional SVM by 6%. The proposed model (FEB-SVM) obtained 98.28% accuracy on training data and a testing accuracy of 93.92%. Along with accuracy, the proposed model obtained a precision of 91.80%, recall of 86.59, F1-score of 89.12%, and Matthew’s correlation coefficient (MCC) of 0.4987. Moreover, the newly proposed model (FEB-SVM) outperforms the 12 state-of-the-art ML models that the researchers have recently presented for dementia prediction.

Place, publisher, year, edition, pages
MDPI, 2023. Vol. 11, no 2, article id 439
Keywords [en]
dementia, feature fusion, machine learning, imbalance classes
National Category
Computer Sciences Bioinformatics (Computational Biology)
Research subject
Family-Centred Health
Identifiers
URN: urn:nbn:se:his:diva-22279DOI: 10.3390/biomedicines11020439ISI: 000938259800001PubMedID: 36830975Scopus ID: 2-s2.0-85148904251OAI: oai:DiVA.org:his-22279DiVA, id: diva2:1737409
Note

CC BY 4.0

This research received no external funding.

Correspondence: peter.anderberg@bth.se

Available from: 2023-02-16 Created: 2023-02-16 Last updated: 2023-05-05Bibliographically approved

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Anderberg, Peter

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