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An Intelligent Learning System for Unbiased Prediction of Dementia Based on Autoencoder and Adaboost Ensemble Learning
Aging Research Center, Karolinska Institutet, Stockholm, Sweden ; Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0003-4190-3532
Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0002-6752-017X
Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0003-4312-2246
University of Skövde, School of Health Sciences. University of Skövde, Digital Health Research (DHEAR). Blekinge Institute of Technology, Department of Health, Sweden.ORCID iD: 0000-0001-9870-8477
2022 (English)In: Life, E-ISSN 2075-1729, Vol. 12, no 7, p. 1-18, article id 1097Article in journal (Refereed) Published
Abstract [en]

Dementia is a neurological condition that primarily affects older adults and there is stillno cure or therapy available to cure it. The symptoms of dementia can appear as early as 10 yearsbefore the beginning of actual diagnosed dementia. Hence, machine learning (ML) researchershave presented several methods for early detection of dementia based on symptoms. However,these techniques suffer from two major flaws. The first issue is the bias of ML models caused byimbalanced classes in the dataset. Past research did not address this issue well and did not takepreventative precautions. Different ML models were developed to illustrate this bias. To alleviate theproblem of bias, we deployed a synthetic minority oversampling technique (SMOTE) to balance thetraining process of the proposed ML model. The second issue is the poor classification accuracy ofML models, which leads to a limited clinical significance. To improve dementia prediction accuracy,we proposed an intelligent learning system that is a hybrid of an autoencoder and adaptive boostmodel. The autoencoder is used to extract relevant features from the feature space and the Adaboostmodel is deployed for the classification of dementia by using an extracted subset of features. Thehyperparameters of the Adaboost model are fine-tuned using a grid search algorithm. Experimentalfindings reveal that the suggested learning system outperforms eleven similar systems which wereproposed in the literature. Furthermore, it was also observed that the proposed learning systemimproves the strength of the conventional Adaboost model by 9.8% and reduces its time complexity.Lastly, the proposed learning system achieved classification accuracy of 90.23%, sensitivity of 98.00%and specificity of 96.65%.

Place, publisher, year, edition, pages
MDPI, 2022. Vol. 12, no 7, p. 1-18, article id 1097
Keywords [en]
balanced accuracy, bachine learning, oversampling, dementia prediction
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:his:diva-21677DOI: 10.3390/life12071097ISI: 000831806600001PubMedID: 35888188Scopus ID: 2-s2.0-85136452905OAI: oai:DiVA.org:his-21677DiVA, id: diva2:1687285
Note

CC BY 4.0

Attribution 4.0 International

(This article belongs to the Special Issue Disease Prediction and Prevention: From Computational Biology and Artificial Intelligence to Epidemiology and Clinical Sciences)

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/life12071097/s1. Table S1: Description of all input variables.Refs. [41,43–48,50,67,68] are cited in Supplementary materials.

This research received no external funding.

Available from: 2022-08-15 Created: 2022-08-15 Last updated: 2022-10-17Bibliographically approved

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Anderberg, Peter

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