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Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans
The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden.
The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden.
University of Skövde, School of Bioscience. University of Skövde, Systems Biology Research Environment. (Bioteknik, Biotechnology)ORCID iD: 0000-0002-6319-4055
The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden.
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2022 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 835, article id 155377Article in journal (Refereed) Published
Abstract [en]

Exposure to toxic metals alters host response and that leads to disease development. Studies have revealed the effects of metals on microbial physiology, however, the role of metal resistant bacteria on host response to metals is unclear. The hypothesis that xenobiotic interactions between gut microbes and arsenic influence the host physiology and toxicity was assessed in a Caenorhabditis elegans model. The arsenic-resistant Lysinibacillus sphaericus B1CDA was fed to C. elegans to determine the host responses to arsenic in comparison to Escherichia coli OP50 food. L. sphaericus diet extended C. elegans lifespan compared to E. coli diet, with an increased expression of genes involved in lifespan, stress response and immunity (hif-1, hsp-16.2, mtl-2, abf-2, clec-60), as well as reduced fat accumulation. Arsenic-exposed worms fed L. sphaericus also had a longer lifespan than those fed E. coli and had an increased expression of genes involved in cytoprotection, stress resistance (mtl-1, mtl-2) and oxidative stress response (cyp-35A2, isp-1, ctl-2, sod-1), together with a decreased accumulation of reactive oxygen species (ROS). In comparison with E. coli, L. sphaericus B1CDA diet increased C. elegans fitness while detoxifying arsenic induced ROS and extending lifespan.

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 835, article id 155377
Keywords [en]
Arsenate, Arsenite, C. elegans, Lifespan, Lysinibacillus sphaericus, Reactive oxygen species, Arsenic, Genes, Linearization, Metals, Oxygen, Physiology, Toxicity, C elegan, E. coli, Elegans, Host response, Lifespans, Lysinibacillus sphericu, Stresses response, Escherichia coli
National Category
Environmental Sciences Biochemistry and Molecular Biology
Research subject
Biotechnology
Identifiers
URN: urn:nbn:se:his:diva-21146DOI: 10.1016/j.scitotenv.2022.155377ISI: 000797863000008PubMedID: 35460794Scopus ID: 2-s2.0-85129450732OAI: oai:DiVA.org:his-21146DiVA, id: diva2:1659110
Funder
Knowledge Foundation, 20180027Knowledge Foundation, 20170118
Note

CC BY 4.0

© 2022 The Authors

20 August 2022

Correspondence Address: Jass, J.; The Life Science Centre-Biology, Sweden; email: jana.jass@oru.se

This work was funded by the Knowledge Foundation Sweden, grants 20180027 and 20170118 (JJ and PEO) and Örebro University.

Available from: 2022-05-19 Created: 2022-05-19 Last updated: 2022-07-12Bibliographically approved

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Mandal, AbulJass, Jana

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