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What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
Department of Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
University of Skövde, School of Health Sciences. University of Skövde, Digital Health Research (DHEAR). Department of Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar ; College of Medicine, Qatar University, Doha, Qatar ; Weill Cornell Medicine – Qatar, Doha, Qatar. (Research on Citizen Centered Health, University of Skövde (Reacch US))ORCID iD: 0000-0003-0961-1302
Department of Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Department of Laboratory Medicine and Pathology, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
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2022 (English)In: International Journal of Surgery Case Reports, E-ISSN 2210-2612, Vol. 91, article id 106751Article in journal (Refereed) Published
Abstract [en]

Introduction: Noninvasive follicular thyroid neoplasm with papillary-like nuclear (NIFTP) is a new entity. No previous study reported prospective cases, outlining using many quantitative and qualitative variables. Methods: Retrospective analysis of all (15) prospective NIFTP cases diagnosed between 2017 and 2021 at our institution. Statistical quantitative analysis outlined demographic, history, ultrasound, histopathology and treatment characteristics. Qualitative analysis examined the cases, with details provided on three cases to highlight the different possible presentations and configurations. Results: Mean age was 41.5 ± 9.91 years, 73.3% were females, and mean BMI was 29.49 ± 5.74 kg/m2. About 87% patients were symptomatic; 86.6% had neck swelling. Ultrasound (US) showed multiple nodules in 71.4% of cases. Fine-needle aspiration cytology (FNAC) showed that follicular lesion of undetermined significance (42.8%) was most common, followed by benign nodule (21.3%). Using the Bethesda System for Reporting Thyroid Cytopathology, 7 cases were category III, 3 category IV, 3 category II, and 1 category I. 60% of patients underwent total thyroidectomy. All cases were diagnosed postoperatively, 2 patients had additional papillary microcarcinoma. In 3 cases, the NIFTP site in the histopathology of resected specimen was different than the US-recommended site of the FNAC. Conclusion: We found discrepancies in the site and diagnosis of the preoperative US recommendation for the FNAC vs the postoperative histopathology of the specimen. These suggest that NIFTP might be incidentally and postoperatively diagnosed, irrespective of US or FNAC findings, hence its ‘true’ incidence might remain underestimated. As NIFTP cases higher BMI, Future research could predict preoperative diagnosis of NIFTP and explore associations with BMI. 

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 91, article id 106751
Keywords [en]
Follicular thyroid neoplasm, NIFTP, Nodule, Noninvasive, Papillary thyroid carcinoma, Papillary-like nuclear features, vitamin D, adult, autoimmune thyroiditis, benign neoplasm, blood vessel calcification, case report, cervical lymphadenopathy, clinical article, cytology, cytopathology, demographics, demography, dysphagia, dyspnea, Egyptian, epilepsy, female, fine needle aspiration biopsy, histopathology, human, human tissue, hypertension, incidence, male, medical history, middle aged, migraine, neck pain, neck swelling, obesity, oncocytoma, papillary carcinoma, Qatari, quantitative analysis, rare disease, retrospective study, Short Survey, thyroid cyst, thyroid hyperplasia, thyroid lobe, thyroid nodule, thyroid tumor, thyroidectomy, toxic goiter, ultrasound
National Category
Cancer and Oncology Surgery
Research subject
Research on Citizen Centered Health, University of Skövde (Reacch US)
Identifiers
URN: urn:nbn:se:his:diva-20951DOI: 10.1016/j.ijscr.2021.106751ISI: 000810725300002PubMedID: 35134690Scopus ID: 2-s2.0-85124211253OAI: oai:DiVA.org:his-20951DiVA, id: diva2:1641803
Note

CC BY-NC-ND 4.0

© 2022 The Author(s)

Corresponding author at: Department of Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar. E-mail address: welansari9@gmail.com (W. El Ansari).

Available from: 2022-03-03 Created: 2022-03-03 Last updated: 2024-01-17Bibliographically approved

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