Everyone gets frustrated over lack of motivation or focus sometimes, but people with ADHD have struggles of related character every single day in their lives. This struggle may be difficult for people to understand. Another factor not well understood is the large discrepancyin the ADHD prevalence between males and females. The most obvious way to study this sex biased male to female ratio of ADHD is by looking at the correlation between sex hormones and ADHD. Moreover, the biggest difference in hormonal profiles between the sexes is the menstrual cycle. Some research exists on testosterone and ADHD but research is limited on more female associated sex hormones such as estradiol. A systematic literature review is now conducted with search words relating to ADHD and estrogen. The results from this review imply that estrogen may mediate ADHD symptom presentation by interacting with other sex hormones. It is further indicated that estrogen receptors may affect ADHD symptom presentation, but this finding needs to be supported by replicating research.