Affective touch represents a key type of social interaction within human relationships and is thus involved in emotional well-being and social attachment. It provokes the synthesis and release of oxytocin (OXT), a neuropeptide associated with the creation and maintenance of social bonds. This study aims to investigate the possible relationships between several genetic polymorphisms -two OXTR SNPs (rs53576 and rs2254298) and four HPA-axis related SNPs (NR3C1 rs41423247, SLC6A4 5-HTTLPR, HTR1A rs6295, and FKBP5 rs1360780)- and the release of plasma oxytocin in response to affective touch. Blood samples were collected from 42 healthy female volunteers while two social interactions were taking place; they received affective touches from both their romantic partner and a stranger, in a randomized order to also check on the impact of social context (data already collected in a previous related research). PCR-RFLPanalysis was performed to genotype the SNP specifically selected in this study (rs2254298), and statistical analyses were conducted to explore these associations taking into consideration if the person touching is the romantic partner or a stranger. Our results show that these SNPs do not appear to be related to the plasma oxytocin response to affective touch, regardless of the toucher and the social context. These findings suggest that the SNPs studied do not have any influence in the oxytocin response in the context analysed and, therefore, could be discarded from further studies or, in contrast, investigated in other oxytocin-related scenarios. Nevertheless, duplication of results in a similar study with bigger data size is recommended.