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A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults
Department of Paediatric Radiology, Karolinska University Hospital, Stockholm, Sweden / Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0002-8730-5901
Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0002-6752-017X
Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden / School of Medical Sciences, Örebro University, Sweden.ORCID iD: 0000-0002-9986-8138
Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.ORCID iD: 0000-0001-9870-8477
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2021 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 110, no 4, p. 1249-1256Article in journal (Refereed) Published
Abstract [en]

Aim To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (rho = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (rho = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Kappa = 0.87-0.94). Conclusion Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 110, no 4, p. 1249-1256
Keywords [en]
growth plate, magnetic resonance imaging, maturation process, obesity, puberty
National Category
Orthopaedics Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:his:diva-19449DOI: 10.1111/apa.15617ISI: 000583231300001PubMedID: 33047349Scopus ID: 2-s2.0-85094635288OAI: oai:DiVA.org:his-19449DiVA, id: diva2:1525634
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CC BY-NC-ND 4.0

First published: 12 October 2020

Available from: 2020-11-13 Created: 2021-02-04 Last updated: 2021-03-30Bibliographically approved

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Luiza Dallora, AnaAnderberg, PeterBerglund, Johan Sanmartin

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Kvist, OlaLuiza Dallora, AnaNilsson, OlaAnderberg, PeterBerglund, Johan SanmartinFlodmark, Carl-Erik
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