Högskolan i Skövde

his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-cv
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Development and evaluation of a cost-effectiveness analysis model for sepsis diagnosis
University of Skövde, School of Bioscience.
2020 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Sepsis is a substantial health care and economic burden worldwide and is one of the most common reasons for admission to the hospital and intensive care unit. Early diagnosis and targeted treatment of sepsis are the bases to reduce the mortality and morbidity. Conventional blood culturing is the gold standard method for sepsis diagnostics. However, blood culturing is a time consuming method, requiring at least 48 to 72 hours to get the first results with very low sensitivity and specificity. The aim of this study was to determine and assess the direct sepsis-related costs for PCR-based diagnostic strategies (SeptiFast and POC/LAB). A mathematical model was constructed to compare PCR-based diagnostic strategies with the conventional blood culturing. Three case scenarios were investigated based on data from the United Kingdom, Spain and the Czech Republic. It was found that, POC/LAB was the most cost effective strategy in all countries if it could reduce the hospitalization length of stay with at least 3 days in the normal hospital ward and 1 day in the intensive care unit. Reducing the hospitalization length of stay had the greatest impact on the economic outcomes. While, reducing the costs of the diagnostic strategies did not show a remarkable effect on the economic results. In conclusion, the findings suggest that PCR-rapid diagnostic methods could be cost-effective for the diagnosis of patients with sepsis if they could reduce the hospitalization length of stay.

Place, publisher, year, edition, pages
2020. , p. 39
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:his:diva-19155OAI: oai:DiVA.org:his-19155DiVA, id: diva2:1472818
Subject / course
Systems Biology
Educational program
Infection Biology - Master’s Programme 120 ECTS
Supervisors
Examiners
Available from: 2020-10-02 Created: 2020-10-02 Last updated: 2020-10-02Bibliographically approved

Open Access in DiVA

fulltext(1241 kB)223 downloads
File information
File name FULLTEXT01.pdfFile size 1241 kBChecksum SHA-512
909410f4bb5228329f58b73ef5c5287fa9e15c2a8366e8acfd4ad8cbdf8039dc8ee5fed3c33d482ff2d7559fe018de2f541427f4e66d31a0ae963b9da2d489ad
Type fulltextMimetype application/pdf

By organisation
School of Bioscience
Bioinformatics and Systems Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 223 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 565 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-cv
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf