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Is there a Connection Between the Gut-Microbiota and Major Depression?
University of Skövde, School of Bioscience.
2020 (English)Independent thesis Basic level (degree of Bachelor), 15 credits / 22,5 HE creditsStudent thesis
Abstract [en]

Major depressive disorder (MDD) is rapidly growing and one of the most common causes of disability and mortality worldwide. People with MDD often display brain changes such as adisrupted balance in neurotransmitters, impaired neurogenesis and neuroplasticity. Traditionally has MDD been treated with medications and talking therapies (psychotherapy). Studies have shown that just around 50 % of people with MDD get improvements from common traditional treatments.Therefore is there a great need for a better understanding of MDD and new treatments. There is now an emerging field of research that indicates that the gut microbiota plays a crucial role in disturbing normal brain functioning in MDD. This connection between the gut and the brain is called the gutbrain axis.The thesis aims to investigate if there is a connection between gut microbiota disruption and MDD and if gut microbiota restoration can be a potential effective future treatment for MDD. Key findings of the thesis were, studies show that people with MDD often display gut microbiota disruption and chronic low grade inflammation. Studies also indicate that this inflammation can cause the specific brain change often displayed in people with MDD. One of the most critical findings in the thesis was that gut brain treatments affect tryptophan metabolism, which affects the risk of MDD. The research area of the gut brain axis is still new and many more studies are needed,particularly in humans.

Place, publisher, year, edition, pages
2020. , p. 35
Keywords [en]
Gut brain axis, Major depressive disorder, Probiotics, G ut microbiota, low grade inflammation, Tryptophan
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:his:diva-19150OAI: oai:DiVA.org:his-19150DiVA, id: diva2:1472338
Subject / course
Cognitive Neuroscience
Educational program
Consciousness Studies - Philosophy and Neuropsychology
Supervisors
Examiners
Available from: 2020-10-01 Created: 2020-10-01 Last updated: 2020-10-01Bibliographically approved

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CiteExportLink to record
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Citation style
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