This literature review examines the default mode network (DMN) and how its role in self related processing and narrative selfhood relates to well-being. The essay explores the DMN in three levels of activity: Firstly in normal function, where mind-wandering is positively correlated with dissatisfaction; Secondly its abnormal function in depression, characterized by excessive activity and rumination; Thirdly in its arguably improved function during mindfulness and meditation, where lower activity is associated with higher well-being, decreased mind-wandering and altered sense of self. The essay shows a relationship between the DMN and well-being, where higher activity correlates with lower well-being.