his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Risk Factors for hypospadias in Northwest Russia: A Murmansk County Birth Registry Study
Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway / International School of Public Health, Northern State Medical University, Arkhangelsk, Russia.
Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway.
Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway.
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Show others and affiliations
2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 4, article id e0214213Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Hypospadias is the most common congenital anomaly of the penis, but its causes are mainly unknown. Of the risk factors identified, the most plausible are hormonal and genetic. The aim of this study was to identify risk factors for hypospadias in Northwest Russia based on registry data.

METHODS: The study population included male infants registered in the Murmansk County Birth Registry between 1 January 2006 and 31 December 2011 (n = 25 475). These infants were followed-up for 2 years using the Murmansk Regional Congenital Defects Registry to identify cases of hypospadias not diagnosed at birth. We used logistic regression analysis to examine the contributions of hypospadias risk factors.

RESULTS: Out of 25 475 male infants born during the study period, 148 had isolated hypospadias. The overall prevalence rate was 54.2 (95% CI 53.6-54.8) per 10 000 male infants. Those born to mothers with preeclampsia (OR = 1.65; 95% CI 1.03-2.66) or infant birthweight < 2500 g (OR = 2.06; 95% CI 1.18-3.60) exhibited increased risk for hypospadias. Maternal age, smoking during pregnancy, folic acid intake during pregnancy or hepatitis B surface antigen positivity did not associate with increased risk of hypospadias.

CONCLUSIONS: Combining data from a birth registry with those from a congenital defects registry provided optimal information about the prevalence of hypospadias and its association with low infant birthweight and preeclampsia. These factors have in common changes in hormone levels during pregnancy, which in turn may have contributed to hypospadias development.

Place, publisher, year, edition, pages
2019. Vol. 14, no 4, article id e0214213
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Individual and Society VIDSOC
Identifiers
URN: urn:nbn:se:his:diva-16752DOI: 10.1371/journal.pone.0214213ISI: 000463314500020PubMedID: 30946760Scopus ID: 2-s2.0-85063936379OAI: oai:DiVA.org:his-16752DiVA, id: diva2:1302873
Available from: 2019-04-07 Created: 2019-04-07 Last updated: 2019-08-06Bibliographically approved

Open Access in DiVA

fulltext(773 kB)43 downloads
File information
File name FULLTEXT01.pdfFile size 773 kBChecksum SHA-512
71de19c8f2011f92a669ef5312756dff32b6a7d61addd02777daeb2078cde87a6083f044147c1567bfce406c25988e317e06d1d94e896e8c3bedb0bea2e2963a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records BETA

Krettek, Alexandra

Search in DiVA

By author/editor
Krettek, Alexandra
By organisation
School of Health and EducationHealth and Education
In the same journal
PLoS ONE
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 43 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 87 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf