his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Role of pterostilbene and blueberries extract in the prevention of pancreatic cancer
University of Skövde, School of Health and Education.
2019 (English)Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Pancreatic cancer occurs when cells in the pancreas begin to duplicate abnormally and form a tumor. The most common type of pancreatic cancer is pancreatic adenocarcinoma, which is an aggressive disease that expands in a symptom free way and have generally advanced at the time of diagnosis. Cell migration is essential in development of pancreas cancer. Cancer develops after the tumor cells infiltrate the peritoneal cavity and achieve metastasis. Recent years increase attention to treat cancer by natural dietary compounds due to their related low toxicity and synergistic effects with current chemotherapeutic factors. Blueberries contain phenolic compounds known as stilbenes (pterostilbene) which has antioxidant and antiproliferation properties. Treatment of pancreatic cancer cells with pterostilbene in vitro results in inhibition of cell proliferation and/or cell death, cell cycle arrest, mitochondrial membrane depolarization, and activation of effector caspase. Blueberries are rich of anthocyanins that has anticancer properties. Pancreatic cancer cell line PANC-1 was treated with different doses of blueberry extract and pterostilbene for different amount of time; 24h, 48h and 72h. Cell viability was measured by MTS assay. The structural assay performed in this study produced conclusive results and significant conclusion that the PANC1 cell viability decreased at 24h 48h and 72h blueberries extract treatment. Cell viability presented as percent of control after 48h blueberry extract treatment showed that the cell numbers were decreased, resulting in 35% of remaining cells after treated with 2% blueberry extract. Moreover, cells that treated with 100µM pterostilbene had significantly decreased cell viability at 24h. Several studies found that pterostilbene and blueberry extract treatment have little or no effect on the growth of normal cells. Hence, it appears pterostilbene’s antioxidant activity is favorable to normal cells but antagonistic to the growth of cancerous cells.

Place, publisher, year, edition, pages
2019. , p. 27
Keywords [en]
pancreatic cancer, blueberry extract, pterostilbene, cell viability, proliferation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:his:diva-16662OAI: oai:DiVA.org:his-16662DiVA, id: diva2:1291750
Subject / course
Biomedicine/Medical Science
Educational program
Biomedicine - Study Programme
Supervisors
Examiners
Available from: 2019-03-01 Created: 2019-02-26 Last updated: 2019-03-04Bibliographically approved

Open Access in DiVA

No full text in DiVA

By organisation
School of Health and Education
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 910 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf