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Volumetric gray matter measures of amygdala and accumbens in childhood overweight/obesity
MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary / Department of Neurology, University of Pecs, Medical School, Hungary.
Department of Pediatrics, University of Pecs, Medical School, Pecs, Hungary.
Utrecht University, Netherlands / Wageningen University & Research, Netherlands.
Leibniz Institute for Prevention Research and Epidemiology BIPS, Bremen, Germany.
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2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 10, article id e0205331Article in journal (Refereed) Published
Abstract [en]

Objectives Neuroimaging data suggest that pediatric overweight and obesity are associated with morphological alterations in gray matter (GM) brain structures, but previous studies using mainly voxel-based morphometry (VBM) showed inconsistent results. Here, we aimed to examine the relationship between youth obesity and the volume of predefined reward system structures using magnetic resonance (MR) volumetry. We also aimed to complement volumetry with VBM-style analysis. Methods Fifty-one Caucasian young subjects (32 females; mean age: 13.8±1.9, range: 10.2–16.5 years) were included. Subjects were selected from a subsample of the I.Family study examined in the Hungarian center. A T1-weighted 1 mm3 isotropic resolution image was acquired. Age- and sex-standardized body mass index (zBMI) was assessed at the day of MRI and ~1.89 years (mean±SD: 689±188 days) before the examination. Obesity related GM alterations were investigated using MR volumetry in five predefined brain structures presumed to play crucial roles in body weight regulation (hippocampus, amygdala, accumbens, caudate, putamen), as well as whole-brain and regional VBM. Results The volumes of accumbens and amygdala showed significant positive correlations with zBMI, while their GM densities were inversely related to zBMI. Voxel-based GM mass also showed significant negative correlation with zBMI when investigated in the predefined amygdala region, but this relationship was mediated by GM density. Conclusions Overweight/obesity related morphometric brain differences already seem to be present in children/adolescents. Our work highlights the disparity between volume and VBM-derived measures and that GM mass (combination of volume and density) is not informative in the context of obesity related volumetric changes. To better characterize the association between childhood obesity and GM morphometry, a combination of volumetric segmentation and VBM methods, as well as future longitudinal studies are necessary. Our results suggest that childhood obesity is associated with enlarged structural volumes, but decreased GM density in the reward system. © 2018 Perlaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Place, publisher, year, edition, pages
Public Library of Science , 2018. Vol. 13, no 10, article id e0205331
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Health Sciences
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Individual and Society VIDSOC
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URN: urn:nbn:se:his:diva-16352DOI: 10.1371/journal.pone.0205331ISI: 000447701300027PubMedID: 30335775Scopus ID: 2-s2.0-85055081179OAI: oai:DiVA.org:his-16352DiVA, id: diva2:1262622
Available from: 2018-11-12 Created: 2018-11-12 Last updated: 2019-09-30Bibliographically approved

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Eiben, Gabriele

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