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Study of potential Anti-cancer effects of Pterostilbene, Blueberry extract and 1,25 vitamin D3 on the viability of Pancreatic cancer cells (PANC-1)
University of Skövde, School of Health and Education.
2018 (English)Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Blueberries, a natural antioxidant and provider of important vitamins have recently increased interest in cancer research. Pterostilbene, a compound found in blueberries seems to exhibit anticancer effects in various cancer types. This study further investigated how pterostilbene as well as blueberry extract itself might influence cancer growth specifically focusing on pancreatic cancer. In addition, the effects of vitamin D on pancreas cancer were also investigated since pancreas cells express a vitamin D receptor. PANC-1 cells were treated with pterostilbene concentrations ranging from 20-100 µM, a vitamin D (1α25(OH)2D3) concentration of 10-8M as well as concentrations of 0.1-2.0% for blueberry extract at time periods of 24, 48- and 72-hours for each treatment. Pterostilbene significantly decreased PANC-1 viability at 100 µM for all time points. Blueberry extract significantly decreased PANC-1 cell viability at all concentrations and time points, however less so at 48 hours. Vitamin D significantly decreased PANC-1 viability after 24 and 48 hours but not at 72 hours. Pterostilbene and blueberry extract probably lead to apoptosis in pancreas cancer due to their effect on cancerogenic mitochondria by elevating pro-apoptotic gene expression leading to cell cycle arrest. Vitamin D might have some effect in pancreas cancer by decreasing the expression Drp1 which is activated by the MAPK pathway but is otherwise a conflicted factor in cancer treatment. In conclusion natural compounds such as pterostilbene show anticancer properties that have currently no side effects which makes them promising agents that might help in future cancer treatment.

Place, publisher, year, edition, pages
2018. , p. 16
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:his:diva-16324OAI: oai:DiVA.org:his-16324DiVA, id: diva2:1257440
Subject / course
Biomedicine/Medical Science
Educational program
Biomedicine - Study Programme
Supervisors
Examiners
Available from: 2018-10-22 Created: 2018-10-20 Last updated: 2018-10-22Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf