This study is motivated by a real-world assembly line in an automotive manufacturing company and it addresses the simple assembly line balancing problem type-E (SALBPE). The SALBPE aims to maximize the balance efficiency (BE) through determining the best combinations of cycle time and station number. To cope with the problem, a mixed integer nonlinear programming (MINLP) model is proposed. The MINLP model differs from the existing ALBPE models as it includes the technological requirements of assembly tasks and optimizes the variation of workload beside the BE. The validity of the proposed model is tested by solving the real-world case study and a set of benchmark problems.