his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Oxidation–reduction potential and sperm DNA fragmentation, and their associations with sperm morphological anomalies amongst fertile and infertile men
Hamad Medical Corporation, Doha, Qatar.
Hamad Medical Corporation, Doha, Qatar.
Hamad Medical Corporation, Doha, Qatar.
Cleveland Clinic Foundation, Cleveland, United States.
Show others and affiliations
2018 (English)In: Arab Journal of Urology, ISSN 2090-598X, Vol. 16, no 1, p. 87-95Article in journal (Refereed) Published
Abstract [en]

Objective: To assess seminal oxidation–reduction potential (ORP) and sperm DNA fragmentation (SDF) in male infertility and their relationships with sperm morphology in fertile and infertile men. Patients and methods: Prospective case-control study comparing the findings of infertile men (n = 1168) to those of men with confirmed fertility (n = 100) regarding demographics and semen characteristics (conventional and advanced semen tests). Spearman rank correlation assessed the correlation between ORP, SDF, and different morphological indices. Means of ORP and SDF were assessed in variable levels of normal sperm morphology amongst all participants. Results: Infertile patients had a significantly lower mean sperm count (32.7 vs 58.7 × 106 sperm/mL), total motility (50.1% vs 60.4%), and normal morphology (5.7% vs 9.9%). Conversely, infertile patients had significantly higher mean head defects (54% vs 48%), and higher ORP and SDF values than fertile controls. ORP and SDF showed significant positive correlations and significant negative correlations with sperm head defects and normal morphology in infertile patients, respectively. ORP and SDF were significantly inversely associated with the level of normal sperm morphology. Using receiver operating characteristic curve analysis, ORP and SDF threshold values of 1.73 mV/106 sperm/mL and 25.5%, respectively, were associated with 76% and 56% sensitivity and 72% and 72.2% specificity, respectively, in differentiating <4% from ≥4% normal morphology. Conclusion: A direct inverse relationship exists between seminal ORP and SDF with various levels of normal sperm morphology. Using ORP and SDF measures in conjunction with standard semen morphology analysis could validate the result of the fertility status of patients. © 2017 Arab Association of Urology

Place, publisher, year, edition, pages
Arab Association of Urology , 2018. Vol. 16, no 1, p. 87-95
Keywords [en]
Male infertility, Oxidation-reduction potential, Sperm, Sperm DNA fragmentation, Sperm morphology
National Category
Health Sciences
Research subject
Individual and Society VIDSOC
Identifiers
URN: urn:nbn:se:his:diva-14978DOI: 10.1016/j.aju.2017.11.014ISI: 000427446800010Scopus ID: 2-s2.0-85041598019OAI: oai:DiVA.org:his-14978DiVA, id: diva2:1192800
Available from: 2018-03-23 Created: 2018-03-23 Last updated: 2018-04-18Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records BETA

El Ansari, Walid

Search in DiVA

By author/editor
El Ansari, Walid
By organisation
School of Health and EducationHealth and Education
Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf