his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Whole-blood fatty acids and inflammation in European children: the IDEFICS Study
Univ Zaragoza, GENUD Growth Exercise NUtr & Dev Res Grp, Fac Hlth Sci, Zaragoza, Spain.
Minist Sci & Innovat, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.;Univ Zaragoza, Dept Prevent Med & Publ Hlth, Zaragoza, Spain.
CNR, Unit Epidemiol & Populat Genet, Inst Food Sci, Avellino, Italy.
Leibniz Inst Prevent Res & Epidemiol BIPS, Dept Epidemiol Methods & Etiol Res, Bremen, Germany / Univ Bremen, Fac Math & Comp Sci, Inst Stat, Bremen, Germany.
Show others and affiliations
2016 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 70, no 7, p. 819-823Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/OBJECTIVES: Fatty acids are hypothesized to influence cardiovascular disease risk because of their effect on inflammation. The aim of this study is to assess the relationship between whole-blood fatty acids (WBFAs) and high-sensitivity C-reactive protein (hs-CRP) in European children. SUBJECTS/METHODS: A total of 1401 subjects (697 boys and 704 girls) aged between 2 and 9 years from the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects in Children and infantS) study were measured in this cross-sectional analysis. The sample was divided into three categories of hs-CRP. Associations between WBFA and hs-CRP were assessed by logistic regression models adjusting for body mass index (BMI), country, age, breastfeeding, mother's education and hours of physical activity. RESULTS: Linoleic acid (LA) (P = 0.013, 95% confidence interval (CI):0.822-0.977) and sum of n-6 WBFA (P = 0.029, 95% CI: 0.866-0.992) concentrations were associated with lower concentrations of hs-CRP in boys. In girls, a high ratio of eicosapentaenoic acid (EPA)/arachidonic acid (AA) was associated (P = 0.018, 95% CI: 0.892-0.989) with lower hs-CRP concentrations. In contrast, sum of blood n-6 highly unsaturated fatty acids (P = 0.012, 95% CI: 1.031-1.284), AA (P = 0.007, 95% CI: 1.053-1.395) and AA/LA ratio (P = 0.005, 95% CI: 1.102-1.703) were associated (P < 0.05) with higher concentrations of hs-CRP in girls. CONCLUSIONS: The n-6 WBFAs (sum of n-6 FA and LA) were associated with lower hs-CRP in boys and with higher hs-CRP in girls (AA, sum of n-6 highly unsaturated and AA/LA ratio). More studies are needed to identify the optimal levels of WBFAs to avoid low-grade inflammation in children considering the differences by sex and BMI.

Place, publisher, year, edition, pages
Nature Publishing Group, 2016. Vol. 70, no 7, p. 819-823
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:his:diva-14420DOI: 10.1038/ejcn.2015.219ISI: 000379613600011PubMedID: 26757836Scopus ID: 2-s2.0-84954350089OAI: oai:DiVA.org:his-14420DiVA, id: diva2:1157602
Note

Group Author(s): IDEFICS Consortium

Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2017-11-27Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Eiben, Gabriele

Search in DiVA

By author/editor
Eiben, Gabriele
In the same journal
European Journal of Clinical Nutrition
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 22 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf