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CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients
Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden / Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. (Bioinformatik, Bioinformatics)ORCID iD: 0000-0003-2899-3801
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. (Bioinformatik, Bioinformatics)ORCID iD: 0000-0003-4697-0590
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden / Department of Neurology, Skåne University Hospital, Lund, Sweden.
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2017 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 59, p. 1-9Article in journal (Refereed) Published
Abstract [en]

A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker associations. Patients in DLB, LAD, VaD, MIX, other, and NOS groups had higher CSF/serum albumin ratio than controls. CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers. Our data show that BBB leakage is common in dementias. The lack of association between CSF/serum albumin ratio and AD biomarkers suggests that BBB dysfunction is not inherent to AD but might represent concomitant cerebrovascular pathology.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 59, p. 1-9
Keywords [en]
Alzheimer's disease, Blood-brain barrier, CSF/serum albumin ratio, Dementia
National Category
Neurology
Research subject
Bioinformatics
Identifiers
URN: urn:nbn:se:his:diva-14035DOI: 10.1016/j.neurobiolaging.2017.06.028ISI: 000411446800001PubMedID: 28779628Scopus ID: 2-s2.0-85026625803OAI: oai:DiVA.org:his-14035DiVA, id: diva2:1135760
Funder
Knowledge FoundationAvailable from: 2017-08-24 Created: 2017-08-24 Last updated: 2017-11-27Bibliographically approved

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Delsing, LouiseSynnergren, Jane

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