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Exercise differentially affects metabolic functions and white adipose tissue in female letrozole-and dihydrotestosterone-induced mouse models of polycystic ovary syndrome
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden / Disciplina de Ginecologia, Laboratorio de Ginecologia Estrutural e Molecular (LIM 58), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden / Endocrinology and Metabolism Laboratory, Department of Medicine, West Division, University of Chile, Santiago, Chile.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
University of Skövde, School of Health and Education. University of Skövde, Health and Education. Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. (Translationell medicin (TRIM), Translational Medicine)ORCID iD: 0000-0003-4616-6789
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2017 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 448, 66-76 p.Article in journal (Refereed) Published
Abstract [en]

Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of large mesenteric adipocytes. LET-exposed mice displayed increased body weight and fat mass, decreased insulin sensitivity, increased frequency of small adipocytes and increased expression of genes related to lipolysis in mesenteric fat. In both models, exercise decreased fat mass and inguinal and mesenteric adipose tissue expression of Notch pathway genes, and restored altered mesenteric adipocytes morphology. In conclusion, exercise restored mesenteric adipocytes morphology in DHT- and LET-exposed mice, and insulin sensitivity and mesenteric expression of lipolysis-related genes in LET-exposed mice. Benefits could be explained by downregulation of Notch, and modulation of browning and lipolysis pathways in the adipose tissue. 

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 448, 66-76 p.
Keyword [en]
Polycystic ovary syndrome, Exercise, Adipose tissue
National Category
Medical and Health Sciences
Research subject
Translational Medicine TRIM
Identifiers
URN: urn:nbn:se:his:diva-13727DOI: 10.1016/j.mce.2017.03.025ISI: 000401218000007PubMedID: 28344042Scopus ID: 2-s2.0-85016551867OAI: oai:DiVA.org:his-13727DiVA: diva2:1112337
Available from: 2017-06-20 Created: 2017-06-20 Last updated: 2017-06-28

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