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Dapagliflozin in patients with type II diabetes mellitus, with and without elevated triglyceride and reduced high-density lipoprotein cholesterol levels
Louisville Metabolic and Atherosclerosis Research Center Inc., Louisville, KY, USA.
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Global Medicines Development, CVMD, AstraZeneca, Gothenburg, Sweden. (Bioinformatik, Bioinformatics)
Biometrics and Information Sciences, AstraZeneca, Gaithersburg, MD, USA.
Global Medicines Development, CVMD, AstraZeneca, Gothenburg, Sweden.
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2017 (English)In: Journal of Clinical Lipidology, ISSN 1933-2874, E-ISSN 1876-4789, Vol. 11, no 2, 450-458 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Dapagliflozin is a selective sodium-glucose cotransporter 2 inhibitor that improves glycemic control in patients with type II diabetes mellitus (T2DM) by reducing renal glucose reabsorption.

OBJECTIVE: The aim was to evaluate the lipid effects of dapagliflozin 10 mg or placebo in patients with T2DM with/without baseline elevated triglyceride and reduced high-density lipoprotein (HDL) cholesterol levels.

METHODS: This was a post hoc analysis of 10 phase 3, placebo-controlled studies of dapagliflozin 10 mg (N = 2237) or placebo (N = 2164) administered for 24 weeks in patients with T2DM. Patients with elevated triglyceride (>= 150 mg/dL [1.69 mmol/L]) and reduced HDL cholesterol levels (<40 mg/dL [1.04 mmol/L] in men; <50 mg/dL [1.29 mmol/L] in women) were included (group A). The reference group (group B) included patients who did not meet the defined lipid criteria.

RESULTS: The effects of dapagliflozin on fasting lipid profiles were generally similar in the 2 lipid groups (ie, groups A and B) and, compared with placebo, were associated with minor increases in non-HDL cholesterol, low-density lipoprotein, and HDL cholesterol levels. The effects on triglyceride levels were inconsistent. The incidence of adverse events (AEs)/serious AEs, and AEs of genital infection, urinary tract infection, volume reduction, renal function, and hypoglycemia were similar in the 2 lipid groups.

CONCLUSION: Patients with T2DM treated with dapagliflozin experienced minor changes in lipid levels; the changes were generally similar in the 2 lipid groups. The clinical significance of these changes in lipids is unclear, especially in view of the positive effects of dapagliflozin on other cardiovascular disease risk factors. 

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 11, no 2, 450-458 p.
Keyword [en]
Dapagliflozin, Dyslipidemia, Type II diabetes mellitus, SGLT2 inhibitors, Cardiovascular
National Category
Basic Medicine Clinical Medicine
Research subject
Bioinformatics
Identifiers
URN: urn:nbn:se:his:diva-13728DOI: 10.1016/j.jacl.2017.01.018ISI: 000402346500018PubMedID: 28502502Scopus ID: 2-s2.0-85015260431OAI: oai:DiVA.org:his-13728DiVA: diva2:1112327
Available from: 2017-06-20 Created: 2017-06-20 Last updated: 2017-11-27Bibliographically approved

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Sartipy, Peter

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