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Relationship between Cognitive and Sleep-wake Variables in Asymptomatic Offspring of Patients with Late-onset Alzheimer's Disease
FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Applied Neuroscience Laboratory, Institute for Biomedical Research, School of Medical Sciences, Universidad Católica Argentina, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina.
FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
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2017 (English)In: Frontiers in Aging Neuroscience, ISSN 1663-4365, E-ISSN 1663-4365, Vol. 9, 93Article in journal (Refereed) Published
Abstract [en]

Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 +/- 0.4 vs. 8.6 +/- 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 +/- 1.3 vs. 44.3 +/- 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 +/- 0.47 h vs. 3.8 +/- 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2017. Vol. 9, 93
Keyword [en]
early diagnosis, late-onset Alzheimer's disease, circadian rhythms, cardiac autonomic control, actigraphy
Identifiers
URN: urn:nbn:se:his:diva-13547DOI: 10.3389/fnagi.2017.00093ISI: 000398725500001OAI: oai:DiVA.org:his-13547DiVA: diva2:1093341
Available from: 2017-05-05 Created: 2017-05-05 Last updated: 2017-05-05

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CiteExportLink to record
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Citation style
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