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Changes in HbA 1c and circulating and adipose tissue androgen levels in overweight‐obese women with polycystic ovary syndrome in response to electroacupuncture
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden / Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.
Institute of Translational Pharmacology – CNR, Rome, Italy.
Institute of Translational Pharmacology – CNR, Rome, Italy.
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2016 (English)In: Obesity Science and Practice, ISSN 2055-2238, Vol. 2, no 4, 426-435 p.Article in journal (Refereed) Published
Abstract [en]

Aim

Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS.

Material and Methods

Seventeen women with PCOS, aged 18 to 38years, with a body mass index (BMI) ≥25 kg/m2 and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole‐body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA1c, circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF).

Results

No significant change in glucose homeostasis was observed, but HbA1c decreased by 9.5% (p=0.004), circulating testosterone decreased by 22% (p=0.0007) and dihydrotestosterone decreased by 12% (p=0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21% (p=0.027) and 20% (p=0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18% (p=0.049), and androstenedione decreased by 13% (p=0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p=0.04). These changes occurred without changes in anthropometrics.

Conclusion

Five weeks of electroacupuncture treatment improves HbA1c and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).

Place, publisher, year, edition, pages
John Wiley & Sons, 2016. Vol. 2, no 4, 426-435 p.
Keyword [en]
Acupuncture, adipose tissue, hyperandrogenism, insulin resistance, sympathetic nervous system
National Category
Endocrinology and Diabetes
Research subject
Medical sciences
Identifiers
URN: urn:nbn:se:his:diva-13217DOI: 10.1002/osp4.78ISI: 000393193700012OAI: oai:DiVA.org:his-13217DiVA: diva2:1054767
Note

Electroacupuncture improves HbA1c in PCOS

Available from: 2016-12-09 Created: 2016-12-09 Last updated: 2017-03-08Bibliographically approved

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CiteExportLink to record
Permanent link

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Citation style
  • apa
  • harvard1
  • ieee
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Output format
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