Change search
ReferencesLink to record
Permanent link

Direct link
Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation
Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden / Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Gastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Show others and affiliations
2016 (English)In: Mucosal Immunology, ISSN 1933-0219, E-ISSN 1935-3456, Vol. 9, no 1, 171-182 p.Article in journal (Refereed) Published
Abstract [en]

Disruption of the homeostatic balance of intestinal dendritic cells (DCs) and macrophages (MQs) may contribute to inflammatory bowel disease. We characterized DC and MQ populations, including their ability to produce retinoic acid, in clinical material encompassing Crohn's ileitis, Crohn's colitis and ulcerative colitis (UC) as well as mesenteric lymph nodes (MLNs) draining these sites. Increased CD14(+)DR(int) MQs characterized inflamed intestinal mucosa while total CD141(+) or CD1c(+) DCs numbers were unchanged. However, CD103(+) DCs, including CD141(+)CD103(+) and CD1c(+)CD103(+) DCs, were reduced in inflamed intestine. In MLNs, two CD14(-) DC populations were identified: CD11c(int)HLADR(hi) and CD11c(hi)HLADR(int) cells. A marked increase of CD11c(hi)HLADR(int) DC, particularly DR(int)CD1c(+) DCs, characterized MLNs draining inflamed intestine. The fraction of DC and MQ populations expressing aldehyde dehydrogenase (ALDH) activity, reflecting retinoic acid synthesis, in UC colon, both in active disease and remission, were reduced compared to controls and inflamed Crohn's colon. In contrast, no difference in the frequency of ALDH(+) cells among blood precursors was detected between UC patients and non-inflamed controls. This suggests that ALDH activity in myeloid cells in the colon of UC patients, regardless of whether the disease is active or in remission, is influenced by the intestinal environment.

Place, publisher, year, edition, pages
2016. Vol. 9, no 1, 171-182 p.
National Category
Gastroenterology and Hepatology Immunology in the medical area
URN: urn:nbn:se:his:diva-13209DOI: 10.1038/mi.2015.48ISI: 000367653800014PubMedID: 26080709ScopusID: 2-s2.0-84953227102OAI: oai:DiVA.org:his-13209DiVA: diva2:1052798
Available from: 2016-12-07 Created: 2016-12-07 Last updated: 2016-12-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopushttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683124/

Search in DiVA

By author/editor
Öhman, Lena
In the same journal
Mucosal Immunology
Gastroenterology and HepatologyImmunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 22 hits
ReferencesLink to record
Permanent link

Direct link