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Adherence to antidepressants among women and men described with trajectory models: a Swedish longitudinal study
Research and Development, Sahlgrenska University Hospital, Gothenburg, Sweden / Section of Epidemiology and Social Medicine, Department of Public Health and Community Medicine at Institute of Medicine, University of Gothenburg, Gothenburg, Sweden / Novo Nordisk A/S, Malmö, Sweden.
Section of Occupational and Environmental Medicine, Department of Public Health and Community Medicine at Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Section of Epidemiology and Social Medicine, Department of Public Health and Community Medicine at Institute of Medicine, University of Gothenburg, Gothenburg, Sweden / Medical Evidence and Observational Research, AstraZeneca, Mölndal, Sweden.
University of Skövde, School of Health and Education. University of Skövde, Health and Education. Nordic School of Public Health, Gothenburg, Sweden. (Fysisk aktivitet, IT och hälsa (FAITH), Physical Activity, IT and Health)ORCID iD: 0000-0003-4616-9525
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2016 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 72, no 11, 1381-1389 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this study are to analyse adherence to antidepressant treatment over 2 years in Sweden among women and men who initiated treatment with citalopram and to identify groups at risk of non-adherence using trajectory models. The study population, including individuals 18-85 years who initiated citalopram use between 1 July 2006 and 30 June 2007, was identified in the Swedish Prescribed Drug Register and followed for 2 years. Adherence was estimated with continuous measure of medication acquisition (CMA) and group-based trajectory modelling, a method which describes adherence patterns over time by estimating trajectories of adherence and the individual's probability of belonging to a specific trajectory. The study population included 54,248 individuals, 64 % women. Mean CMA was 52 % among women and 50 % among men (p < 0.001). Five different adherence patterns (Trajectories) were identified. Similar proportion of women and men belonged to each Trajectory. Around 29 % of the women and 27 % of the men belonged to the Trajectory which showed full adherence throughout the 2-year study period. The other four Trajectories showed adherence that declined to different degrees and at different stages in time. Having low socioeconomic status was more common among individuals in Trajectories showing declining adherence than in the adherent Trajectory. Using trajectory modelling, five Trajectories describing different patterns of adherence to citalopram treatment over time were identified. A large proportion discontinued treatment early and having low socioeconomic status increased the risk of being non-adherent.

Place, publisher, year, edition, pages
Springer, 2016. Vol. 72, no 11, 1381-1389 p.
Keyword [en]
Medication adherence, Swedish prescribed drug register, Gender, Antidepressants, Trajectory models
National Category
Social and Clinical Pharmacy Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:his:diva-13073DOI: 10.1007/s00228-016-2106-1ISI: 000385175700011ScopusID: 2-s2.0-84982854124OAI: oai:DiVA.org:his-13073DiVA: diva2:1044420
Available from: 2016-11-03 Created: 2016-11-03 Last updated: 2017-02-14Bibliographically approved

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CiteExportLink to record
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