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MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity
Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden. (Bioinformatik, Bioinformatics)ORCID-id: 0000-0002-0402-1437
Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. (Bioinformatik, Bioinformatics)ORCID-id: 0000-0003-4697-0590
Takara Bio Europe AB, Gothenburg, Sweden.
Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Vise andre og tillknytning
2016 (engelsk)Inngår i: Toxicology in Vitro, ISSN 0887-2333, E-ISSN 1879-3177, Vol. 34, s. 26-34Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic drugs used for treatment of a variety of cancers, including solid tumors, leukemia, lymphomas, and breast cancer. The successful use of doxorubicin has, however, been hampered by severe cardiotoxic side-effects. In order to prevent or reverse negative side-effects of doxorubicin, it is important to find early biomarkers of heart injury and drug-induced cardiotoxicity. The high stability under extreme conditions, presence in various body fluids, and tissue-specificity, makes microRNAs very suitable as clinical biomarkers. The present study aimed towards evaluating the early and late effects of doxorubicin on the microRNA expression in cardiomyocytes derived from human pluripotent stem cells. We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin. Investigation of the biological relevance of the identified microRNAs revealed connections to cardiomyocyte function and cardiotoxicity, thus supporting the findings of these microRNAs as potential biomarkers for drug-induced cardiotoxicity.

sted, utgiver, år, opplag, sider
Elsevier, 2016. Vol. 34, s. 26-34
HSV kategori
Forskningsprogram
Bioinformatik
Identifikatorer
URN: urn:nbn:se:his:diva-12339DOI: 10.1016/j.tiv.2016.03.009ISI: 000379273800004PubMedID: 27033315Scopus ID: 2-s2.0-84962362050OAI: oai:DiVA.org:his-12339DiVA, id: diva2:934169
Tilgjengelig fra: 2016-06-08 Laget: 2016-06-08 Sist oppdatert: 2018-07-31bibliografisk kontrollert
Inngår i avhandling
1. In vitro toxicity testing using human pluripotent stem cell derivatives
Åpne denne publikasjonen i ny fane eller vindu >>In vitro toxicity testing using human pluripotent stem cell derivatives
2016 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
University of Gothenburg, 2016. s. 82
Emneord
toxicity testing, human pluripotent stem cells, cardiomyocytes, hepatocytes, microarray, quantitative proteomics, bioinformatics, transcriptomics, microRNA
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
urn:nbn:se:his:diva-13340 (URN)978-91-629-0001-4 (ISBN)978-91-629-0002-1 (ISBN)
Disputas
2016-12-15, 09:00 (engelsk)
Opponent
Veileder
Merknad

I avhandlingen ingår även:

Holmgren, G., Sartipy, P., Andersson, C.X., Lindahl, A., and Synnergren, J. Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin – integration and visualization of multi omics data Manuscript

Tilgjengelig fra: 2017-11-27 Laget: 2017-01-26 Sist oppdatert: 2018-07-31bibliografisk kontrollert

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