his.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals
University of Rajshahi, Bangladesh / Islamic University, Kushtia-7003, Bangladesh.
University of Rajshahi, Rajshahi-6205, Bangladesh.
Islamic University, Kushtia-7003, Bangladesh.
University of Rajshahi, Rajshahi-6205, Bangladesh.
Vise andre og tillknytning
2015 (engelsk)Inngår i: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 14, nr 1, artikkel-id 92Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Cardiovascular diseases (CVDs) and cancers are the major causes of chronic arsenic exposure-related morbidity and mortality. Matrix metalloproteinase-2 (MMP-2) and −9 (MMP-9) are deeply involved in the pathogenesis of CVDs and cancers. This study has been designed to evaluate the interactions of arsenic exposure with serum MMP-2 and MMP-9 concentrations especially in relation to the circulating biomarkers of CVDs.

Methods: A total of 373 human subjects, 265 from arsenic-endemic and 108 from non-endemic areas in Bangladesh were recruited for this study. Arsenic concentrations in the specimens were measured by inductively coupled plasma mass spectroscopy (ICP-MS) and serum MMPs were quantified by immunoassay kits.

Results: Serum MMP-2 and MMP-9 concentrations in arsenic-endemic population were significantly (p < 0.001) higher than those in non-endemic population. Both MMPs showed significant positive interactions with drinking water (rs = 0.208, p < 0.001 for MMP-2; rs = 0.163, p <0.01 for MMP-9), hair (rs= 0.163, p < 0.01 for MMP-2; rs = 0.173, p < 0.01 for MMP-9) and nail (rs= 0.160, p < 0.01 for MMP-2; rs = 0.182, p < 0.001 for MMP-9) arsenic of the study subjects. MMP-2 concentrations were 1.02, 1.03 and 1.05 times, and MMP-9 concentrations were 1.03, 1.06 and 1.07 times greater for 1 unit increase in log-transformed water, hair and nail arsenic concentrations, respectively, after adjusting for covariates (age, sex, BMI, smoking habit and hypertension). Furthermore, both MMPs were increased dose-dependently when the study subjects were split into three (≤10, 10.1-50 and > 50 μg/L) groups based on the regulatory upper limit of water arsenic concentration set by WHO and Bangladesh Government. MMPs were also found to be significantly (p < 0.05) associated with each other. Finally, the concentrations of both MMPs were correlated with several circulating markers related to CVDs.

Conclusions: This study showed the significant positive associations and dose–response relationships of arsenic exposure with serum MMP-2 and MMP-9 concentrations. This study also showed the interactions of MMP-2 and MMP-9 concentrations with the circulating markers of CVDs suggesting the MMP-2 and MMP-9 -mediated mechanism of arsenic-induced CVDs.

sted, utgiver, år, opplag, sider
BioMed Central, 2015. Vol. 14, nr 1, artikkel-id 92
Emneord [en]
Arsenic, MMP-2, MMP-9, Cardiovascular diseases, Cancer, Bangladesh
HSV kategori
Forskningsprogram
Naturvetenskap; Bioteknik
Identifikatorer
URN: urn:nbn:se:his:diva-11752DOI: 10.1186/s12940-015-0079-7ISI: 000366085600001PubMedID: 26637202Scopus ID: 2-s2.0-84949512940OAI: oai:DiVA.org:his-11752DiVA, id: diva2:881937
Tilgjengelig fra: 2015-12-11 Laget: 2015-12-11 Sist oppdatert: 2019-10-31bibliografisk kontrollert

Open Access i DiVA

fulltext(553 kB)294 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 553 kBChecksum SHA-512
b37495bb74fd4636ced25cb8aad047dc3a5270e2d3c37567b582ca74e48351292b8bd953b2f2e80c2964a3e034e528f563bdb8924f9ee9fa57c726ae9860dc2d
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Rahman, AminurMandal, Abul

Søk i DiVA

Av forfatter/redaktør
Rahman, AminurMandal, Abul
Av organisasjonen
I samme tidsskrift
Environmental health

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 294 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 863 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf