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Explore transcription factor profiles in human pluripotent stem cells
Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. (Bioinformatics)ORCID-id: 0000-0003-4697-0590
2014 (Engelska)Ingår i: 6th International Conference on Bioinformatics and Computational Biology (BICoB 2014): Las Vegas, Nevada, USA, 24 – 26 March 2014 / [ed] F. Saeed, B. DasGupta, International Society for Computers and Their Applications , 2014, s. 197-202Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

Human pluripotent stem cells (hPSCs) have unique properties of proliferation and self-renewal, and can be differentiated into various functional cell types. The differentiation processes are to a large extent controlled by transcription factors, which are key cellular components that control gene expression and determine how cells respond to the environment on various stimuli. Surprisingly little is known about the transcription factor activity in hPSCs, and more knowledge is needed about the transcriptional regulation during the differentiation processes. This information will be instrumental for development of efficient differentiation protocols to produce fully functional specialized cell types, for use in drug discovery and toxicity testing studies. This paper explores the expression of transcription factors in hPSCs, and gives an overview of the genomic organization of transcription factors, which likely are involved in the fate decision processes of hPSCs. In total 1,323 human transcription factors were selected from literature and further investigated for their genomic organization and their expression in hPSCs. Moreover, transcription factors that are highly expressed in undifferentiated hPSCs, compared to their differentiated progenies are identified and further investigated for protein-protein interaction activity using computational tools. The protein-protein interaction networks presented here will provide valuable information about the regulatory mechanisms, and reveal important proteins involved in the maintenance of the pluripotent state of stem cells.

Ort, förlag, år, upplaga, sidor
International Society for Computers and Their Applications , 2014. s. 197-202
Nationell ämneskategori
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Forskningsämne
Bioinformatik
Identifikatorer
URN: urn:nbn:se:his:diva-10231Scopus ID: 2-s2.0-84905863089ISBN: 978-1-63266-514-0 (tryckt)OAI: oai:DiVA.org:his-10231DiVA, id: diva2:766654
Konferens
6th international conference on Bioinformatics and Computational Biology (BICoB) Las Vegas, 24-26 March 2014
Forskningsfinansiär
KK-stiftelsen, 2012/0310Tillgänglig från: 2014-11-27 Skapad: 2014-11-27 Senast uppdaterad: 2018-07-31Bibliografiskt granskad

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Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

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