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Assessing chronic pelvic pain syndrome patients: Blood plasma factors and cortisol saliva
Högskolan i Skövde, Institutionen för vård och natur. Högskolan i Skövde, Forskningscentrum för Systembiologi. (Fysiologi, farmakologi och toxikologi (P2T))ORCID-id: 0000-0002-6549-086X
Skaraborgs Sjukhus, Skövde , Sweden.
Kärnsjukhuset, Skövde , Sweden.
Högskolan i Skövde, Institutionen för vård och natur. (Folkhälsa)
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2013 (Engelska)Ingår i: Scandinavian Journal of Urology, ISSN 2168-1813, Vol. 47, nr 6, s. 521-528Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective. The aim of this study was to identify changes in inflammatory molecules in the blood (plasma) of patients with chronic prostatitis/chronic pelvic syndrome (CP/CPPS) compared with controls. Altered levels indicate a systemic component by possible involvement of the prostate and/or the inner pelvic floor musculature. Material and methods. In 32 patients with CP/CPPS and 37 controls, blood plasma levels of testosterone, macrophage migration inhibitory factor (MIF), tumour necrosis factor-alpha (TNF-alpha), TNF-beta, interleukin-2 (IL-2) and IL-1 beta were measured by enzyme-linked immunosorbent assay. Cortisol in saliva samples was measured in the morning and late evening. All participants answered a questionnaire regarding their health profile. Results. Significantly higher levels of MIF (p = 0.012) were detected in patients. The testosterone level was, contrary to other studies, little lower in patients (p = 0.014; age adjusted). When controls with health issues and patients with a parallel disease were excluded, the MIF and TNF-alpha levels were higher in the patients (p = 0.007, p = 0.016, respectively) than in controls, and the testosterone was slightly lower in patients (p = 0.047). Conclusions. The findings show an immune response extending to the circulatory system, in which MIF makes a significant contribution to CP/CPPS. This study also indicates TNF-alpha as a circulatory component when excluding subjects with concomitant diseases. Both MIF and TNF-alpha have previously been highlighted for other diseases related to chronic pain and here also for CP/CPPS. These results provide further insights into the immunological basis of CP/CPPS.

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Informa Healthcare, 2013. Vol. 47, nr 6, s. 521-528
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:his:diva-8783DOI: 10.3109/21681805.2013.769460ISI: 000328899000013PubMedID: 23394140Scopus ID: 2-s2.0-84890518365OAI: oai:DiVA.org:his-8783DiVA, id: diva2:696624
Tillgänglig från: 2014-02-14 Skapad: 2014-02-14 Senast uppdaterad: 2017-11-27Bibliografiskt granskad

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Lundh, DanGifford, MervynLarsson, Dennis

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