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Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh .
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh .
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh / Islamic Univ, Dept Appl Nutr & Food Technol, Kushtia 7003, Bangladesh / UMP, FIST, Gambang 26300, Pahang, Malaysia .
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh .
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2011 (Engelska)Ingår i: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 10, s. 64-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Chronic arsenic exposure has been shown to cause liver damage. However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented. The aim of our study was to investigate the dose-response relationship between arsenic exposure and major serum enzyme marker activity associated with LFTs in the population living in arsenic-endemic areas in Bangladesh. Methods: A total of 200 residents living in arsenic-endemic areas in Bangladesh were selected as study subjects. Arsenic concentrations in the drinking water, hair and nails were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). The study subjects were stratified into quartile groups as follows, based on concentrations of arsenic in the drinking water, as well as in subjects' hair and nails: lowest, low, medium and high. The serum hepatic enzyme activities of alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT) were then assayed. Results: Arsenic concentrations in the subjects' hair and nails were positively correlated with arsenic levels in the drinking water. As regards the exposure-response relationship with arsenic in the drinking water, the respective activities of ALP, AST and ALT were found to be significantly increased in the high-exposure groups compared to the lowest-exposure groups before and after adjustments were made for different covariates. With internal exposure markers (arsenic in hair and nails), the ALP, AST and ALT activity profiles assumed a similar shape of dose-response relationship, with very few differences seen in the higher groups compared to the lowest group, most likely due to the temporalities of exposure metrics. Conclusions: The present study demonstrated that arsenic concentrations in the drinking water were strongly correlated with arsenic concentrations in the subjects' hair and nails. Further, this study revealed a novel exposure- and dose- response relationship between arsenic exposure metrics and serum hepatic enzyme activity. Elevated serum hepatic enzyme activities in the higher exposure gradients provided new insights into arsenic-induced liver toxicity that might be helpful for the early prognosis of arsenic-induced liver diseases.

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BioMed Central, 2011. Vol. 10, s. 64-
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Miljövetenskap
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Naturvetenskap
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URN: urn:nbn:se:his:diva-5533DOI: 10.1186/1476-069X-10-64ISI: 000293342700001Scopus ID: 2-s2.0-79959974151OAI: oai:DiVA.org:his-5533DiVA, id: diva2:510951
Tillgänglig från: 2012-03-19 Skapad: 2012-03-01 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

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