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RNA interference and its therapeutic potential
University of Copenhagen.
Flinders University.
Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för vård och natur.
2011 (engelsk)Inngår i: Central European Journal of Medicine, ISSN 1895-1058, E-ISSN 1644-3640, Vol. 6, nr 2, s. 137-147Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

RNA interference is a technique that has become popular in the past few years. This is a biological method to detect the activity of a specific gene within a cell. RNAi is the introduction of homologous double stranded RNA to specifically target a gene’s product resulting in null or hypomorphic phenotypes. This technique involves the degradation of specific mRNA by using small interfering RNA. Both microRNA (miRNA) and small interfering RNA (siRNA) are directly related to RNA interference. RNAi mechanism is being explored as a new technique for suppressing gene expression. It is an important issue in the treatment of various diseases. This review considers different aspects of RNAi technique including its history of discovery, molecular mechanism, gene expression study, advantages of this technique against previously used techniques, barrier associated with this technique, and its therapeutic application.

sted, utgiver, år, opplag, sider
Versita , 2011. Vol. 6, nr 2, s. 137-147
Emneord [en]
Cancer, MircoRNA, Interfering RNA, Disease
HSV kategori
Forskningsprogram
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:his:diva-5195DOI: 10.2478/s11536-011-0005-5ISI: 000287452100001Scopus ID: 2-s2.0-79956374124OAI: oai:DiVA.org:his-5195DiVA, id: diva2:429223
Tilgjengelig fra: 2011-07-04 Laget: 2011-07-04 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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