Högskolan i Skövde

his.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • apa-cv
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Investigation of phylogenetic relationships using microRNA sequences and secondary structures
Högskolan i Skövde, Institutionen för vård och natur.
2010 (Engelska)Självständigt arbete på avancerad nivå (magisterexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
Abstract [en]

MicroRNAs are important biomolecules for regulating biological processes. Moreover, the secondary structure of microRNA is important for its activity and has been used previously as a mean for finding unknown microRNAs. A phylogenetic study of the microRNA secondary structure reveals more information than its primary sequence, because the primary sequence can undergo mutations that give rise to different phylogenetic relationships, whereas the secondary structure is more robust against mutations and therefore sometimes  more informative.

Here we constructed a phylogenetic tree entirely based on microRNA secondary structures using tools PHYLIP (Felsenstein, 1995) and RNAforester (Matthias Höchsmann, 2003, Hochsmann et al., 2004), and compared the overall topology and clusters with the phylogenetic tree constructed using microRNA sequence. The purpose behind this comparison was to investigate the sequence and structure similarity in phylogenetic context and also to investigate if functionally similar microRNA genes are closer in their structure-derived phylogenetic tree.

Our phylogenetic comparison shows that the sequence similarity has hardly any effect on the structure similarity in the phylogenetic tree. MicroRNAs that have similar function are closer in the phylogenetic tree based on secondary structure than its respective sequence phylogeny. Hence, this approach can be very useful in predicting the functions of the new microRNAs whose function is yet to be known, since the function of the miRNAs heavily relies on its secondary structure.

 

Ort, förlag, år, upplaga, sidor
2010. , s. 22
Nyckelord [en]
microrna secondary structure, phylogeny, phylogenetic tree, carcinoma tumor
Nationell ämneskategori
Genetik
Identifikatorer
URN: urn:nbn:se:his:diva-4478OAI: oai:DiVA.org:his-4478DiVA, id: diva2:373900
Presentation
(Engelska)
Uppsök
medicin
Handledare
Examinatorer
Tillgänglig från: 2010-12-06 Skapad: 2010-12-02 Senast uppdaterad: 2010-12-06Bibliografiskt granskad

Open Access i DiVA

fulltext(1870 kB)1106 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1870 kBChecksumma SHA-512
4436865ee424e21395c30de689ff72649346c22af9107a06d114a57e977bcf5952b4857b22961cfa7a9bf56b3659dc1490cc2d2a3c0edbf411ce421da9729684
Typ fulltextMimetyp application/pdf

Sök vidare i DiVA

Av författaren/redaktören
Dnyansagar, Rohit
Av organisationen
Institutionen för vård och natur
Genetik

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 1108 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

urn-nbn

Altmetricpoäng

urn-nbn
Totalt: 606 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • apa-cv
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf