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Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden
Research School of Health and Welfare, School of Health and Welfare, University of Jönköping, Sweden.
University of Skövde, School of Bioscience. University of Skövde, Systems Biology Research Environment. (Translational Bioinformatics)ORCID iD: 0000-0001-9242-4852
Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Jönköping, Sweden ; Department of Clinical Physiology, County Hospital Ryhov, Jönköping, Sweden ; Unit of Cardiovascular Sciences, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Department of Biology and Biology Engineering, Chalmers University of Technology, Gothenburg, Sweden.
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 12670Article in journal (Refereed) Published
Abstract [en]

Numerous studies have shown that lifestyle factors, such as regular physical activity and vitamin D intake, may remarkably improve overall health and mental wellbeing. This is especially important in older adults whose vitamin D deficiency occurs with a high prevalence. This study aimed to examine the influence of lifestyle and vitamin D on global DNA methylation patterns in an elderly cohort in Southwest of Sweden. We also sought to examine the methylation levels of specific genes involved in vitamin D's molecular and metabolic activated pathways. We performed a genome wide methylation analysis, using Illumina Infinium DNA Methylation EPIC 850kBeadChip array, on 277 healthy individuals from Southwest Sweden at the age of 70-95. The study participants also answered queries on lifestyle, vitamin intake, heart medication, and estimated health. Vitamin D intake did not in general affect methylation patterns, which is in concert with other studies. However, when comparing the group of individuals taking vitamin supplements, including vitamin D, with those not taking supplements, a difference in methylation in the solute carrier family 25 (SCL25A24) gene was found. This confirms a previous finding, where changes in expression of SLC25A24 were associated with vitamin D treatment in human monocytes. The combination of vitamin D intake and high physical activity increased methylation of genes linked to regulation of vitamin D receptor pathway, the Wnt pathway and general cancer processes. To our knowledge, this is the first study detecting epigenetic markers associated with the combined effects of vitamin D supplementation and high physical activity. These results deserve to be further investigated in an extended, interventional study cohort, where also the levels of 25(OH)D3 can be monitored.

Place, publisher, year, edition, pages
Nature Portfolio , 2022. Vol. 12, no 1, article id 12670
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Bioinformatics
Identifiers
URN: urn:nbn:se:his:diva-21658DOI: 10.1038/s41598-022-15924-xISI: 000830116000026PubMedID: 35879377Scopus ID: 2-s2.0-85134761700OAI: oai:DiVA.org:his-21658DiVA, id: diva2:1685990
Funder
Swedish Research Council, 2018-05973
Note

CC BY 4.0

© 2022 Springer Nature Limited

Correspondence and requests for materials should be addressed to S.K. sandra.karlsson@ju.se

We thank the “Aktiva seniorer” association in Sweden for their collaboration in this study. The computations in this study were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX), partially funded by the Swedish Research Council through Grant Agreement No. 2018-05973.

Open access funding provided by Jönköping University. The University of Borås and the University of Skövde provided with funding for the different experiments performed in this study. Jönköping University supplied with the necessary resources to carry out this investigation.

Available from: 2022-08-08 Created: 2022-08-08 Last updated: 2022-10-14Bibliographically approved

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Ulfenborg, Benjamin

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