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Expression Analysis of Human Endometrial Adenocarcinoma in an Inbred Rat Model
Högskolan i Skövde, Institutionen för vård och natur.
Högskolan i Skövde, Institutionen för vård och natur.
2008 (Engelska)Ingår i: Hormonal Carcinogenesis: Proceedings of the Fifth International Symposium, Springer , 2008, s. 503-509Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

Endometrial cancer (EC) is the most abundant female gynaecologic malignancy, ranking fourth in incidence among invasive tumors in women. Hormone-related (estrogen-dependent) EC is the prevalent subtype and accounts for approximately 75% of these cancers. Females of the BDII inbred rat strain are extremely prone to endometrial adenocarcinoma, (EAC) and approximately 90% of virgin females spontaneously develop EAC during their life span. Thus, these rats serve as a useful model for the genetic analysis of this malignancy. In the present work, gene expression profiling, by means of cDNA microarrays, was performed on cDNA from endometrial tumor cell lines and from cell lines derived from nonmalignant lesions/normal tissues of the endometrium without specific findings (WSF). We identified numerous genes differentially expressed between endometrial cell lines and WSFs employing clustering analysis and statistical inference analysis. Many of the genes identified are located within or close to the chromosomal regions earlier identified to be associated with EAC susceptibility and development. Several of the genes identified are involved in pathways commonly altered in carcinogenesis, such as the TGF-pathway.

Ort, förlag, år, upplaga, sidor
Springer , 2008. s. 503-509
Serie
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 617
Nationell ämneskategori
Biokemi och molekylärbiologi
Forskningsämne
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:his:diva-2732DOI: 10.1007/978-0-387-69080-3ISI: 000253701800050Scopus ID: 2-s2.0-46749125797ISBN: 978-0-387-69078-0 OAI: oai:DiVA.org:his-2732DiVA, id: diva2:160083
Konferens
International symposium on Hormonal Carcinogenesis
Tillgänglig från: 2009-02-11 Skapad: 2009-02-11 Senast uppdaterad: 2017-11-27Bibliografiskt granskad

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Karlsson, SandraKlinga-Levan, Karin

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Totalt: 941 träffar
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