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Rare presentation of primary varicella zoster as fatal fulminant hepatitis in adult on low-dose, short-term steroid: Case report
Department of General Surgery, Hamad Medical Corporation, Doha, Qatar.
Högskolan i Skövde, Institutionen för hälsa och lärande. Högskolan i Skövde, Forskningsspecialiseringen Hälsa och Lärande. Department of Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar / College of Medicine, Qatar University, Doha, Qatar. (Individ och samhälle VIDSOC, Individual and Society)ORCID-id: 0000-0003-0961-1302
Department of General Surgery, Hamad Medical Corporation, Doha, Qatar.
Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
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2019 (engelsk)Inngår i: Annals of Medicine and Surgery, ISSN 2049-0801, Vol. 48, s. 115-117Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Varicella zoster virus presents clinically as primary (chickenpox) or secondary (herpes zoster) infection. Cutaneous and extracutaneous dissemination may occur, usually in immunocompromised patients. VZV hepatitis that progresses to fulminant hepatic failure is very rare and fatal. To the best of our knowledge, 9 cases have been reported to date, of which 7 were in immunocompromised adults, and only one patient was on short duration steroid therapy. Presentation of case: We present a 26-year old man who was admitted initially with acute abdomen as query persistent biliary colic. Later, he showed clinical and laboratory findings of VZV hepatitis that progressed rapidly despite maximal medical ICU support and he expired on day 3 of admission. Conclusions: Acute VZV infection may present as fulminant hepatitis. The presentation may initially be challenging for the diagnosis and should be considered if the patient has been in contact with a sick case. Low dose corticosteroid could carry a risk for fatal VZV fulminant hepatitis and should be used very cautiously especially with VZV patients’ contacts. Further causative relationships remain to be established. 

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 48, s. 115-117
Emneord [en]
Biliary colic, Case report, Fulminant acute hepatic failure, Hepatitis, Liver failure
HSV kategori
Forskningsprogram
Individ och samhälle VIDSOC
Identifikatorer
URN: urn:nbn:se:his:diva-17904DOI: 10.1016/j.amsu.2019.10.034ISI: 000500308200026PubMedID: 31763037Scopus ID: 2-s2.0-85074811478OAI: oai:DiVA.org:his-17904DiVA, id: diva2:1372064
Tilgjengelig fra: 2019-11-21 Laget: 2019-11-21 Sist oppdatert: 2019-12-19bibliografisk kontrollert

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