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CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients
Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden / Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. (Bioinformatik, Bioinformatics)ORCID-id: 0000-0003-2899-3801
Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. (Bioinformatik, Bioinformatics)ORCID-id: 0000-0003-4697-0590
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden / Department of Neurology, Skåne University Hospital, Lund, Sweden.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 59, s. 1-9Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker associations. Patients in DLB, LAD, VaD, MIX, other, and NOS groups had higher CSF/serum albumin ratio than controls. CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers. Our data show that BBB leakage is common in dementias. The lack of association between CSF/serum albumin ratio and AD biomarkers suggests that BBB dysfunction is not inherent to AD but might represent concomitant cerebrovascular pathology.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 59, s. 1-9
Emneord [en]
Alzheimer's disease, Blood-brain barrier, CSF/serum albumin ratio, Dementia
HSV kategori
Forskningsprogram
Bioinformatik; INF502 Biomarkörer
Identifikatorer
URN: urn:nbn:se:his:diva-14035DOI: 10.1016/j.neurobiolaging.2017.06.028ISI: 000411446800001PubMedID: 28779628Scopus ID: 2-s2.0-85026625803OAI: oai:DiVA.org:his-14035DiVA, id: diva2:1135760
Forskningsfinansiär
Knowledge FoundationTilgjengelig fra: 2017-08-24 Laget: 2017-08-24 Sist oppdatert: 2019-02-14bibliografisk kontrollert

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