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A prospective exploration of symptom burden clusters in women with breast cancer during chemotherapy treatment
Högskolan i Skövde, Institutionen för hälsa och lärande. Högskolan i Skövde, Forskningsspecialiseringen Hälsa och Lärande. Department of Neurobiology, Care Science and Society, Division of Nursing, Karolinska Institutet, Huddinge, Sweden. (Äldre och långvariga hälsoproblem, Health and Ageing)ORCID-id: 0000-0003-0976-531X
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Research and Development Centre, Skaraborg Hospital, Skövde, Sweden.
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Supportive Care in Cancer, ISSN 0941-4355, E-ISSN 1433-7339, Vol. 25, nr 5, s. 1423-1429Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose

The aim was to prospectively map symptom clusters in patients with stage I–IIIa breast cancer during standard chemotherapy treatment in a randomised study.

Methods

Participants completed the Memorial Symptom Assessment Scale (MSAS) at baseline, day 12 after the first and third cycle of FEC 75 or FEC 100, and day 12 after the last cycle of Taxotere. Cut-off values for symptom scores, a mean value based on each individual reporting a symptom including occurrence, frequency, severity and distress for inclusion in analysis, were determined.

Results

The symptom burden cluster analysis was conducted in two steps and included symptoms with high frequency and high levels of distress. The factor analysis revealed three symptom clusters; physical, gastro (phys/gastro) and emotional, with core symptoms that remained stable over time. The most prevalent symptoms for the total sample during all cycles were as follows: lack of energy (range between 48 and 90%), feeling sad (48–79%), difficulty sleeping (54–78%), difficulty concentrating (53–74%), worrying (54–74%) and pain (29–67%).

Conclusion

In summary, we have prospectively established that symptom clusters remain stable over time with a basis of core symptoms. This knowledge will aid in the development of effective core symptom-focused interventions to minimise symptom burden for patients treated with chemotherapy for breast cancer.

sted, utgiver, år, opplag, sider
2017. Vol. 25, nr 5, s. 1423-1429
Emneord [en]
Breast cancer, Chemotherapy, Patient reported outcome measures, Symptom, Symptom cluster
HSV kategori
Identifikatorer
URN: urn:nbn:se:his:diva-13243DOI: 10.1007/s00520-016-3527-1ISI: 000399153200009PubMedID: 27981366Scopus ID: 2-s2.0-85006138053OAI: oai:DiVA.org:his-13243DiVA, id: diva2:1057608
Tilgjengelig fra: 2016-12-19 Laget: 2016-12-19 Sist oppdatert: 2017-12-08bibliografisk kontrollert

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